Related Experiment Video

Updated: Feb 4, 2026

In Vivo Imaging and Quantitation of the Host Angiogenic Response in Zebrafish Tumor Xenografts
11:07

In Vivo Imaging and Quantitation of the Host Angiogenic Response in Zebrafish Tumor Xenografts

Published on: August 14, 2019

7.5K

Angiogenic Imbalance as a Contributor of Preeclampsia

Weronika Dymara-Konopka1, Marzena Laskowska1, Anna Błażewicz2

  • 1Department of Obstetrics and Perinatology, Medical University of Lublin, Poland, 20-950 Lublin, Jaczewskiego 8, Poland.

Current Pharmaceutical Biotechnology
|September 27, 2018
PubMed

Insights

Preeclampsia, a serious pregnancy condition, involves imbalances in angiogenic factors. Understanding these biomarkers offers promising future clinical management strategies for maternal and fetal health.

Area of Science:

  • Obstetrics and Gynecology
  • Maternal-Fetal Medicine
  • Cardiovascular Biology

Background:

  • Preeclampsia affects 3-6% of pregnancies, causing significant maternal and fetal morbidity/mortality.
  • Its exact cause is unknown, but placental antiangiogenic factors are implicated.
  • Key molecules include excess soluble fms-like tyrosine kinase 1 (sFlt-1) and soluble endoglin (sEng), and deficient placental growth factor (PlGF) and vascular endothelial growth factor A (VEGF-A).

Purpose of the Study:

  • To review current knowledge on angiogenic biomarkers in preeclampsia.
  • To analyze the predictive, diagnostic, and therapeutic potential of these biomarkers.
  • To discuss the background and future clinical applications of circulating angiogenic factors.

Main Methods:

  • Literature review of recent studies on preeclampsia pathogenesis.
  • Analysis of the role of specific pro- and antiangiogenic molecules.
  • Evaluation of biomarker utility in clinical settings.

Main Results:

  • Imbalances in sFlt-1, sEng, PlGF, and VEGF-A are central to preeclampsia.
  • These biomarkers show potential for prediction, diagnosis, and therapy.
  • Circulating angiogenic factors offer promising avenues for managing preeclampsia.

Conclusions:

  • Angiogenic biomarkers are crucial in understanding and potentially managing preeclampsia.
  • Further research and accessible diagnostic tools are needed, especially for developing countries.

Keywords:
PlGFPreeclampsiaVEGFangiogenic factorshypertensionpregnancysEngsFlt-1.

More Related Videos

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro10:47

Standardized and Scalable Assay to Study Perfused 3D Angiogenic Sprouting of iPSC-derived Endothelial Cells In Vitro

Published on: November 6, 2019

31.2K
Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo08:19

Transfer of Manipulated Tumor-associated Neutrophils into Tumor-Bearing Mice to Study their Angiogenic Potential In Vivo

Published on: July 20, 2019

6.5K

Related Concept Videos

Homeostatic Imbalance01:10

Homeostatic Imbalance

Homeostasis is the maintenance of a stable internal environment within the body, which is crucial for the proper functioning of cells, tissues, organs, and organ systems. The body has various control mechanisms that work together to regulate various physiological parameters such as temperature, blood pressure, pH balance, and fluid balance, to name a few. These control mechanisms are based on feedback loops that can be either positive or negative.
However, sometimes these feedback loops fail,...
34.9K
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
3.0K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
4.2K
Blood Pressure Imbalances and Circulatory Shock01:24

Blood Pressure Imbalances and Circulatory Shock

Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.7K
Titration Calculations: Weak Acid - Strong Base03:55

Titration Calculations: Weak Acid - Strong Base

Calculating pH for Titration Solutions: Weak Acid/Strong Base
For the titration of 25.00 mL of 0.100 M CH3CO2H with 0.100 M NaOH, the reaction can be represented as:
49.3K
Protein and Protein Structure02:15

Protein and Protein Structure

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
87.9K