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Competition02:34

Competition

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When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
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Habitat Fragmentation02:31

Habitat Fragmentation

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Habitat fragmentation describes the division of a more extensive, continuous habitat into smaller, discontinuous areas. Human activities such as land conversion, as well as slower geological processes leading to changes in the physical environment, are the two leading causes of habitat fragmentation. The fragmentation process typically follows the same steps: perforation, dissection, fragmentation, shrinkage, and attrition.
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Strategies for Assessing and Addressing Confounding01:25

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Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
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C4 Pathway and CAM01:27

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Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
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Protein Complex Assembly02:41

Protein Complex Assembly

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Proteins can form homomeric complexes with another unit of the same protein or heteromeric complexes with different types.  Most protein complexes self-assemble spontaneously via ordered pathways, while some proteins need assembly factors that guide their proper assembly. Despite the crowded intracellular environment, proteins usually interact with their correct partners and form functional complexes.
Many viruses self-assemble into a fully functional unit using the infected host cell to...
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Mass Spectrometry: Alkene Fragmentation00:59

Mass Spectrometry: Alkene Fragmentation

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Alkenes lose one electron from the unsaturated π bond upon ionization and form stable molecular ions. Further fragmentation of alkenes occurs through three different reaction pathways. The most prominent fragmentation is the cleavage at the allylic position. The resultant allylic carbocation is resonance stabilized. In the mass spectra of terminal alkenes, this fragment appears at a mass-to-charge ratio of 41. In the internal alkenes, where there are two choices of allylic cleavage, the...
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Updated: Feb 4, 2026

Simulation of a Scaled Assembly Process with Collaboration of a Robotic Arm and Monitoring through a Vision System for Quality Control
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Controlling Fragment Competition on Pathways to Addressable Self-Assembly.

Jim Madge, David Bourne, Mark A Miller

    The Journal of Physical Chemistry. B
    |September 27, 2018
    PubMed
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    We developed a "completability" algorithm to manage competition in addressable self-assembly. This method helps design efficient pathways for creating complex molecular structures with unique building blocks.

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    Area of Science:

    • Chemical Engineering
    • Materials Science
    • Computational Chemistry

    Background:

    • Addressable self-assembly uses unique building blocks for precise structure formation.
    • Restrictions in block placement can limit self-assembly efficiency and yield.
    • Overlapping fragments can compete, hindering successful assembly.

    Purpose of the Study:

    • To introduce a "completability" algorithm for quantifying fragment competition.
    • To deduce principles for suppressing fragment incompatibility in self-assembly.
    • To optimize the design of addressable self-assembly systems.

    Main Methods:

    • Development of a "completability" algorithm.
    • Analysis of bonding networks and their role in competition.
    • Simulation of self-assembly for two distinct 20-component targets.

    Main Results:

    • Quantified competition between self-assembling fragments.
    • Identified loops in bonding networks as a source of competition.
    • Demonstrated suppression of competition through careful network design and semihierarchical pathways.

    Conclusions:

    • Fragment incompatibility is a key challenge in addressable self-assembly.
    • The "completability" algorithm provides a framework for designing efficient self-assembly pathways.
    • Optimized bonding networks and semihierarchical assembly strategies can overcome competition, improving yield and efficiency.