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Updated: Feb 4, 2026

Protocols for Vaginal Inoculation and Sample Collection in the Experimental Mouse Model of Candida vaginitis
Published on: December 8, 2011
Effect of pea protein plus grape seed dry extract on a murine model of Candida albicans induced vaginitis
Emanuela Esposito1, Michela Campolo1, Giovanna Casili1
1Department of Chemical, Biological, Pharmacological & Environmental Sciences, University of Messina, Italy.
Aim:
The objective of this research was to evaluate the antifungal properties of the association between grape seed and pea by using a nonpharmacological medical device that contains them.
Materials & Methods:
A murine model of vulvovaginal candidiasis, induced by Candida albicans infection, was used.
Results:
We showed that topical treatment with the device significantly reduced the fungal burden in vagina and preserved vagina tissue architecture from C. albicans infection.
Conclusion:
We can support the potential beneficial effect of the association between grape and pea extract present in the medical device. Together these results supported this device as a favorable antifungal agent and a promising synergist with fluconazole in the clinical management of vulvovaginal candidiasis caused by C. albicans biofilms.
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