Related Experiment Video

Updated: Feb 4, 2026

Anterior Cervical Discectomy and Fusion in the Ovine Model
06:11

Anterior Cervical Discectomy and Fusion in the Ovine Model

Published on: October 5, 2009

13.3K

Postoperative Seroma Formation After Posterior Cervical Fusion with Use of RhBMP-2: A Report of Two Cases

Nathan R Wanderman1, Nicholas J Drayer2, Marko Tomov1

  • 1Department of Orthopedic Surgery, Mayo Clinic, Rochester, Minnesota.

JBJS Case Connector
|September 27, 2018
PubMed
Abstract

Insights

Recombinant human bone morphogenetic protein-2 (rhBMP-2) may increase seroma risk after posterior cervical fusion. Surgeons should consider drains and imaging for symptomatic patients to manage this complication.

Area of Science:

  • Spinal Surgery
  • Orthopedics
  • Biomaterials

Background:

  • Posterior cervical fusion is a surgical procedure to stabilize the cervical spine.
  • Recombinant human bone morphogenetic protein-2 (rhBMP-2) is used off-label to promote bone healing in spinal fusion.
  • Complication rates associated with off-label rhBMP-2 use in cervical spine surgery are not well-documented.

Observation:

  • Two cases of postoperative seroma formation after posterior cervical fusion using rhBMP-2 are presented.
  • Seroma is a collection of fluid that can occur after surgery.

Findings:

  • The use of rhBMP-2 in posterior cervical fusion is associated with an increased risk of seroma formation.
  • This complication may necessitate the use of a postoperative drain.

Implications:

  • Surgeons should be aware of the potential risk of seroma when using rhBMP-2 in posterior cervical fusion.
  • Postoperative drains may be required to manage seromas.
  • A low threshold for obtaining magnetic resonance imaging (MRI) in symptomatic patients is recommended to diagnose and manage potential complications.

More Related Videos

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible10:42

A Postoperative Evaluation Guideline for Computer-Assisted Reconstruction of the Mandible

Published on: January 28, 2020

7.0K
Live Imaging of Mouse Secondary Palate Fusion06:10

Live Imaging of Mouse Secondary Palate Fusion

Published on: July 27, 2017

8.0K

Related Concept Videos

Nuclear Fusion02:45

Nuclear Fusion

The process of converting very light nuclei into heavier nuclei is also accompanied by the conversion of mass into large amounts of energy, a process called fusion. The principal source of energy in the sun is a net fusion reaction in which four hydrogen nuclei fuse and ultimately produce one helium nucleus and two positrons.
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
33.9K
Data Reporting and Recording01:24

Data Reporting and Recording

Reporting and recording are crucial in data documentation. The timely, thorough, and accurate documentation of facts is essential when recording patient data. Failure to record findings during an assessment or interpretation of a problem will result in loss of information and make the patient document unreliable. The reader is left with general impressions if the information is not specific. A recording is documenting data of the individual's health information in a traceable, secure, and...
5.5K
Types of Reports I: Hands-off Report01:25

Types of Reports I: Hands-off Report

A hand-off report, also known as a change-of-shift report, is a crucial nursing process that ensures the smooth transition of patient care responsibilities between nursing staff.
Following are the key components and categories of hand-off reports:
Purpose and Process:
1.5K
Tagging and Fusion Proteins01:24

Tagging and Fusion Proteins

Proteins are involved in several cellular processes and biochemical reactions. Analyzing a specific protein of interest requires it to be isolated from the other proteins in the cell. This is achieved by overexpressing the specific gene in a suitable host to produce large quantities of the target protein. A tag or label is recombined with the gene to produce a fusion protein containing the target protein and the tag. The tags on these fusion proteins can then be used for easy detection and...
8.5K
SNAREs and Membrane Fusion01:43

SNAREs and Membrane Fusion

Once a transport vesicle has recognized its target organelle, the vesicular membrane needs to fuse with the target membrane to unload the cargo. Transmembrane proteins called SNAREs present on organelle membranes and their vesicles, mediate vesicle fusion.
SNAREs exist in pairs that symmetrically interact and catalyze the fusion of the lipid bilayers in vesicle and target organelle. v-SNARE in the vesicle membrane are single polypeptide chains that bind to a complementary t-SNARE, composed of 2...
12.8K
Formation of Complex Ions03:45

Formation of Complex Ions

A type of Lewis acid-base chemistry involves the formation of a complex ion (or a coordination complex) comprising a central atom, typically a transition metal cation, surrounded by ions or molecules called ligands. These ligands can be neutral molecules like H2O or NH3, or ions such as CN− or OH−. Often, the ligands act as Lewis bases, donating a pair of electrons to the central atom. These types of Lewis acid-base reactions are examples of a broad subdiscipline called coordination...
26.1K