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Updated: Feb 4, 2026

Generation and Maintenance of Primate Induced Pluripotent Stem Cells Derived from Urine
Published on: July 28, 2023
Stat3 activation is critical for pluripotency maintenance
Yan Zhang1,2, Dan Wang2,3, Jia Xu1,2
1Department of Cell Biology, School of Medicine, Nankai University, Tianjin, China.
Abstract:
Signal transducer and activator of transcription 3 (Stat3) is a cytoplasmic transcription with many important functions, including regulation of cell proliferation, differentiation, survival, angiogenesis, and immune response. Besides, it plays critical roles in regulating the pluripotency. With the ability of self-renewal and differentiation, embryonic stem (ES) cells provide an unlimited source for cell transplantation. ES cells can maintain its undifferentiated state with leukemia inhibitory factor, the role which is achieved by the activation of the Stat3 pathway. Moreover, Stat3 activation is necessary for the naïve state maintenance of the ES cells and somatic stem cells reprogramming. This study presents an overview of the critical roles of Stat3 activation in the pluripotency maintenance of ES cells, somatic cell reprogramming, and naïve-primed pluripotent states conversion of ES cells.
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