IL1R1 and IL1R2 polymorphisms were associated with tuberculosis risk: A pilot study

Area of Science:

• Genetics
• Immunology
• Infectious Diseases

Background:

• Interleukin-1 (IL-1) is implicated in tuberculosis (TB) development.
• IL1R1 and IL1R2 genes encode a key component of the IL-1 receptor.
• Limited research exists on IL1R1 and IL1R2 gene polymorphisms in TB patients.

Purpose of the Study:

• To investigate the association between single-nucleotide polymorphisms (SNPs) in IL1R1 and IL1R2 and the risk of developing tuberculosis (TB).
• To evaluate the role of specific genetic variations in TB susceptibility within the Chinese Han population.

Main Methods:

• Genotyping of nine single-nucleotide polymorphisms (SNPs) in IL1R1 and IL1R2 genes.
• Case-control study involving 300 TB patients and 300 healthy controls.
• Statistical analysis using unconditional logistic regression, adjusting for age and gender, to calculate odds ratios and 95% confidence intervals.

Main Results:

• The minor allele 'A' of rs4851527 in IL1R2 was associated with a reduced risk of TB.
• Minor alleles of rs10490571, rs956730, and rs3917225 in IL1R1 were linked to an increased TB risk (p < 0.05).
• Three specific haplotypes (TGCT, TGTT, and GA) were significantly associated with an increased risk of TB (p < 0.05).

Conclusions:

• Genetic polymorphisms in IL1R1 and IL1R2 are associated with tuberculosis susceptibility.
• These findings provide new insights into the genetic basis of TB in the Chinese Han population.
• Specific SNPs and haplotypes within IL1R1 and IL1R2 may serve as potential biomarkers for TB risk assessment.