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Tertiary Lymphoid Structures: Autoimmunity Goes Local.

Elena Pipi1,2, Saba Nayar1, David H Gardner1

  • 1Rheumatology Research Group, Institute of Inflammation and Ageing, University of Birmingham, Birmingham, United Kingdom.

Frontiers in Immunology
|September 28, 2018
PubMed
Summary
This summary is machine-generated.

Tertiary lymphoid structures (TLS) found in autoimmune diseases drive chronic inflammation and the survival of self-reactive immune cells. These structures promote the development of harmful autoantibodies, worsening disease progression.

Keywords:
B-cellsautoantibodiesgerminal center responseglycosylationtertiary lymphoid structures (TLS)

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Area of Science:

  • Immunology
  • Pathology

Background:

  • Tertiary lymphoid structures (TLS) resemble secondary lymphoid organs and are found in autoimmune disease tissues.
  • TLS support local adaptive immune responses to self-antigens.

Purpose of the Study:

  • To review the role of TLS in autoimmune disease pathogenesis.
  • To highlight TLS contribution to chronic inflammation, autoreactive lymphocyte survival, and autoantibody pathogenicity.

Main Methods:

  • Literature review focusing on tertiary lymphoid structures in autoimmune diseases.

Main Results:

  • TLS are associated with disease progression, autoantibody production, and malignancy.
  • TLS sustain inflammatory responses and the survival of autoreactive lymphocytes.
  • TLS influence post-translational modifications of autoantibodies, increasing their pathogenicity.

Conclusions:

  • TLS play a critical role in the persistence and exacerbation of autoimmune diseases.
  • Understanding TLS mechanisms is crucial for developing targeted therapies for autoimmune conditions.