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Area of Science:

  • Neuro-oncology
  • Ophthalmology
  • Neurology

Background:

  • Carboplatin is a widely used platinum-based chemotherapy agent for solid tumors.
  • Peripheral neuropathy is a known side effect of carboplatin.
  • Ocular motor cranial neuropathies are not previously reported as a side effect.

Observation:

  • A patient receiving intra-arterial carboplatin for glioblastoma multiforme developed ocular motor cranial nerve palsies.
  • Specifically, the patient experienced persistent third and fourth nerve palsies.
  • Nerve function did not recover even after discontinuation of carboplatin therapy.

Findings:

  • This case highlights a potential, previously unreported, ocular toxicity of carboplatin.
  • Persistent third and fourth nerve palsies represent a rare adverse event associated with carboplatin administration.
  • The cranial nerve deficits were irreversible in this reported instance.

Implications:

  • Clinicians should be aware of the possibility of ocular motor cranial nerve palsies as a rare side effect of carboplatin.
  • Further research is warranted to understand the mechanism and incidence of carboplatin-induced ocular neuropathy.
  • This finding may influence treatment monitoring and patient counseling for patients undergoing carboplatin therapy.