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Insulin allergy can be successfully managed by a systematic approach.

Maija Bruun Haastrup1, Jan Erik Henriksen2, Charlotte Gotthard Mortz3

  • 11Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark.

Clinical and Translational Allergy
|September 28, 2018
PubMed
Summary

A systematic approach effectively diagnoses and manages Type I insulin allergy. This method helps identify patients needing specific treatments, ensuring symptom relief and better diabetes control.

Keywords:
AllergyIgEInsulinIntracutaneous test

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Area of Science:

  • Allergy and Immunology
  • Endocrinology
  • Dermatology

Background:

  • Type I insulin allergy diagnosis lacks international consensus, posing challenges for clinicians.
  • Current diagnostic methods like specific IgE and skin testing have limitations in correlating with clinical symptoms.
  • A systematic approach was developed at Odense University Hospital since 2003 to evaluate suspected insulin allergy.

Purpose of the Study:

  • To establish a systematic diagnostic and treatment protocol for patients with suspected insulin allergy.
  • To evaluate the effectiveness of a comprehensive approach in managing insulin allergy.
  • To improve patient outcomes and symptom relief in insulin-allergic individuals.

Main Methods:

  • Retrospective data retrieval from 2003-2017 of patients evaluated for insulin allergy.
  • Inclusion of comprehensive medical history, specific IgE testing for insulin, and intracutaneous testing (ICT) with various insulins.
  • Analysis of diagnostic test results and subsequent treatment strategies.

Main Results:

  • 144 patients were evaluated; 110 had negative specific IgE.
  • Of 34 patients with positive tests, 31 showed positive ICT results, all with mild symptoms.
  • Management included antihistamines, oral antidiabetics, insulin switching, or insulin pumps for complex cases.

Conclusions:

  • A systematic approach enables effective diagnosis and management of insulin allergy.
  • Symptom relief and improved diabetes management are achievable for most patients with insulin allergy.
  • This systematic strategy provides a framework for clinical practice in managing insulin allergy.