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Normocomplementaemic urticarial vasculitis: effective treatment with omalizumab.
Marianne de Brito1, Gisela Huebner2, DedeeF Murrell1
11Department of Dermatology, St George Hospital, University of New South Wales, Sydney, Australia.
Clinical and Translational Allergy
|September 28, 2018
Summary
Two patients with normocomplementaemic urticarial vasculitis showed significant improvement with omalizumab treatment. Further clinical trials are recommended for this condition.
Area of Science:
- Immunology
- Dermatology
- Rheumatology
Background:
- Normocomplementaemic urticarial vasculitis (NUV) is a rare autoimmune condition.
- Urticarial vasculitis can be classified based on complement levels.
- Limited treatment options exist for NUV.
Purpose of the Study:
- To report the efficacy of omalizumab in NUV.
- To compare findings with hypocomplementaemic urticarial vasculitis syndrome (HUVS).
- To advocate for clinical trials of omalizumab in NUV.
Main Methods:
- Case report of two NUV patients.
- Observation of treatment response to omalizumab.
- Literature review comparing NUV and HUVS.
Main Results:
- Both patients with NUV experienced an impressive response to omalizumab.
- Omalizumab appears effective in managing NUV symptoms.
- This contrasts with existing literature on HUVS.
Conclusions:
- Omalizumab shows promise as a treatment for NUV.
- Clinical trials are warranted to confirm omalizumab's efficacy in NUV.
- Distinguishing NUV from HUVS is crucial for treatment considerations.
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