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ESR1 mutations: Pièce de résistance

Berry Button1, Ben Ho Park1,2

  • 1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.

Genes & Diseases
|September 28, 2018
PubMed

Insights

Endocrine therapies are crucial for estrogen receptor-positive breast cancer, but resistance is common. This review explores mechanisms of resistance and new treatments to overcome it.

Area of Science:

  • Oncology
  • Endocrinology
  • Cancer Biology

Background:

  • Estrogen and estrogen receptor-alpha (ER) signaling drive ER-positive breast cancer.
  • Endocrine therapies targeting ER are standard treatment for ER-positive breast cancer.
  • Resistance to endocrine therapy, both de novo and acquired, is a significant clinical challenge.

Purpose of the Study:

  • To review the mechanisms underlying endocrine therapy resistance in ER-positive breast cancer.
  • To discuss the development of alternative treatments to overcome endocrine resistance.
  • To highlight the integration of resistance mechanisms and therapeutic strategies.

Main Methods:

  • Literature review of studies on endocrine therapy resistance in ER-positive breast cancer.
  • Analysis of current research on resistance mechanisms.
  • Synthesis of findings on novel therapeutic approaches.

Main Results:

  • Multiple mechanisms contribute to endocrine therapy resistance.
  • Emerging therapies show promise in overcoming resistance.
  • Integrating mechanistic insights with treatment strategies is crucial for clinical success.

Conclusions:

  • Understanding resistance mechanisms is key to developing effective treatments.
  • Novel therapeutic strategies are being developed to combat endocrine resistance.
  • Personalized treatment approaches may improve outcomes for resistant breast cancer.
Keywords:
Breast cancerCirculating tumor DNAESR1Estrogen receptorMutationPlasma

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