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A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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ESR1 mutations: Pièce de résistance.
Berry Button1, Ben Ho Park1,2
1The Sidney Kimmel Comprehensive Cancer Center, The Johns Hopkins University School of Medicine, Baltimore, MD, United States.
Genes & Diseases
|September 28, 2018
Summary
Endocrine therapies are crucial for estrogen receptor-positive breast cancer, but resistance is common. This review explores mechanisms of resistance and new treatments to overcome it.
Area of Science:
- Oncology
- Endocrinology
- Cancer Biology
Background:
- Estrogen and estrogen receptor-alpha (ER) signaling drive ER-positive breast cancer.
- Endocrine therapies targeting ER are standard treatment for ER-positive breast cancer.
- Resistance to endocrine therapy, both de novo and acquired, is a significant clinical challenge.
Purpose of the Study:
- To review the mechanisms underlying endocrine therapy resistance in ER-positive breast cancer.
- To discuss the development of alternative treatments to overcome endocrine resistance.
- To highlight the integration of resistance mechanisms and therapeutic strategies.
Main Methods:
- Literature review of studies on endocrine therapy resistance in ER-positive breast cancer.
- Analysis of current research on resistance mechanisms.
- Synthesis of findings on novel therapeutic approaches.
Main Results:
- Multiple mechanisms contribute to endocrine therapy resistance.
- Emerging therapies show promise in overcoming resistance.
- Integrating mechanistic insights with treatment strategies is crucial for clinical success.
Conclusions:
- Understanding resistance mechanisms is key to developing effective treatments.
- Novel therapeutic strategies are being developed to combat endocrine resistance.
- Personalized treatment approaches may improve outcomes for resistant breast cancer.
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