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Updated: Feb 4, 2026
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CRISPR-mediated Genome Editing of the Human Fungal Pathogen Candida albicans
Published on: November 14, 2018
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CRISPR-mediated genome editing and human diseases.
Liquan Cai1, Alfred L Fisher2,3, Haochu Huang4
1Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, Weisberg Engineering Complex, Marshall University, 1628 Third Avenue, Huntington, WV 25703, USA.
Genes & Diseases
|September 28, 2018
Summary
CRISPR gene editing technology offers powerful tools for understanding gene function and treating diseases like Barth syndrome and cystic fibrosis. CRISPR/Cas9 enables precise DNA correction in various models, advancing biomedical research and therapeutic applications.
Area of Science:
- Biotechnology
- Genetics
- Molecular Biology
Background:
- CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology is a revolutionary genome editing tool.
- Initially used for basic research, it is now pivotal in studying and treating human diseases.
Purpose of the Study:
- To review the diverse applications of CRISPR/Cas9 technology in biomedical research and human disease treatment.
- To highlight its potential in genetic disease correction, immunology, and regenerative medicine.
Main Methods:
- CRISPR/Cas9 genome editing to correct DNA mutations in vitro and in vivo.
- Application in immunology for targeting specific genes and creating chimeric antigen receptors.
- Integration with induced pluripotent stem (iPS) cells for tissue engineering.
Main Results:
- Successful correction of disease-causing mutations in various genetic disorders.
- Advancements in immunological applications, including potential treatments for AIDS and enhanced anti-tumor immunotherapy.
- Development of genetically modified animals for producing biologic materials and creation of disease models using iPS cells.
Conclusions:
- CRISPR/Cas9 technology is a versatile and powerful tool with transformative potential in medicine.
- It opens new avenues for treating genetic diseases, advancing immunotherapy, and enabling tissue engineering.
- Continued research promises further breakthroughs in human health and disease management.
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