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Related Experiment Videos

Sleep Abnormalities in Wilson's Disease.

Valérie Cochen De Cock1,2, Nadège Girardot-Tinant3,4, France Woimant3,4

  • 1Sleep Unit, Beau Soleil Clinic, 119 Avenue de Lodève, 34070, Montpellier, France. valerie.cochen@gmail.com.

Current Treatment Options in Neurology
|September 28, 2018
PubMed
Summary
This summary is machine-generated.

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Wilson's disease (WD) frequently causes sleep disorders like insomnia and REM sleep behavior disorder (RBD). Early identification of these sleep issues may enable timely WD treatment and symptom resolution.

Area of Science:

  • Neurology
  • Sleep Medicine
  • Genetics

Background:

  • Wilson's disease (WD) is a genetic disorder of copper metabolism.
  • Neurological and psychiatric symptoms are common in WD.
  • Sleep disturbances are increasingly recognized as a significant feature of WD.

Purpose of the Study:

  • To review sleep disorders associated with Wilson's disease.
  • To explore the underlying mechanisms of these sleep disorders.
  • To discuss current and potential treatments for sleep disturbances in WD.

Main Methods:

  • Literature review of studies on sleep disorders in Wilson's disease.
  • Analysis of reported sleep symptoms, including insomnia, daytime sleepiness, restless legs syndrome (RLS), cataplexy-like episodes, and REM sleep behavior disorder (RBD).
Keywords:
Cataplexy-like episodesInsomniaPeriodic limb movementsREM sleep behavior disorderRestless legs syndromeSleepinessWilson’s disease

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  • Examination of proposed pathomechanisms and treatment strategies.

    • Main Results:

    • Sleep disorders are frequent in WD patients, manifesting as insomnia, excessive daytime sleepiness, RLS, cataplexy-like episodes, and REM sleep behavior disorder (RBD).
    • Sleep disturbances can present as prodromal symptoms of WD, offering a window for early diagnosis and intervention.
    • Mechanisms are multifactorial, involving neurological pathway lesions, treatment side effects, and motor, autonomic, or metabolic dysfunctions.

    Conclusions:

    • Sleep disorders are a common and significant comorbidity in Wilson's disease.
    • Recognizing sleep disorders can aid in early WD detection and management.
    • Further research is needed to fully elucidate mechanisms and optimize therapeutic approaches for sleep disturbances in WD.