Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Melanocortins, neural plasticity and aging.

W H Gispen, R L Isaacson, B M Spruijt

    Progress in Neuro-Psychopharmacology & Biological Psychiatry
    |January 1, 1986
    PubMed
    Summary

    Peptides like alpha-melanocyte-stimulating hormone (alpha-MSH) support neural health. Chronic melanocortin treatment may help prevent age-related brain diseases by improving neural plasticity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dynamic magnetic resonance imaging and spectroscopie of experimental brain injury.

    Acta neuropsychiatrica·2016
    Same author

    Neuropeptides as psychotropic drugs.

    Acta neuropsychiatrica·2016
    Same author

    Tactical deception to hide sexual behaviour: macaques use distance, not visibility.

    Behavioral ecology and sociobiology·2015
    Same author

    Sneaky monkeys: an audience effect of male rhesus macaques (Macaca mulatta) on sexual behavior.

    American journal of primatology·2013
    Same author

    Long-tailed macaques (Macaca fascicularis) understand what conspecifics can see in a competitive situation.

    Animal cognition·2013
    Same author

    High-throughput phenotyping of avoidance learning in mice discriminates different genotypes and identifies a novel gene.

    Genes, brain, and behavior·2012

    Area of Science:

    • Neuroscience
    • Endocrinology
    • Pharmacology

    Background:

    • Peptides derived from adrenocorticotropic hormone (ACTH) and alpha-melanocyte-stimulating hormone (alpha-MSH) exhibit trophic effects on nervous system structures.
    • Age-related decline in neural plasticity is a potential factor in brain diseases.
    • Melanocortins are known to enhance the adaptive capacities of the nervous system.

    Purpose of the Study:

    • To investigate the potential of melanocortins to counteract age-related brain pathology.
    • To explore the neurotrophic effects of melanocortin-derived peptides.

    Main Methods:

    • Review of existing literature on melanocortins and neural plasticity.
    • Analysis of studies investigating the effects of chronic melanocortin treatment on nervous system function.

    Main Results:

    • Melanocortins demonstrate a capacity to improve the nervous system's adaptational abilities.
    • Evidence suggests that chronic melanocortin administration may mitigate age-related changes in brain structures.

    Conclusions:

    • Melanocortins hold promise as a therapeutic strategy for age-related neurological conditions.
    • Targeting neural plasticity with melanocortins could be a key approach to combating brain aging.

    Related Experiment Videos