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Related Concept Videos

Psychoneuroimmunology: Cardiovascular Disease01:27

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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Related Experiment Video

Updated: Feb 4, 2026

Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Circular RNAs in Cardiovascular Diseases.

Lijun Wang1,2, Xiangmin Meng1,2, Guoping Li3

  • 1Cardiac Regeneration and Ageing Lab, Institute of Cardiovascular Sciences, School of Life Science, Shanghai University, Shanghai, China.

Advances in Experimental Medicine and Biology
|September 28, 2018
PubMed
Summary

Circular RNAs (circRNAs) are key regulators in cardiovascular diseases, acting as miRNA sponges and interacting with proteins. This review highlights their roles and potential as biomarkers for cardiovascular conditions.

Keywords:
Cardiovascular diseasesCircular RNARNA-binding proteinmicroRNA

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Last Updated: Feb 4, 2026

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Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are generated by mRNA back-splicing and are abundant in eukaryotes.
  • circRNAs are implicated in various biological processes and diseases, including cardiovascular conditions.

Purpose of the Study:

  • To review recent advancements in circRNA research within cardiovascular diseases.
  • To outline the regulatory roles of circRNAs in the cardiovascular system.
  • To discuss potential mechanisms and biomarker applications of circRNAs.

Main Methods:

  • Literature review of current research on circRNAs in cardiovascular diseases.
  • Analysis of identified circRNAs and their functions (e.g., miRNA sponges, protein interactions).
  • Discussion of regulatory mechanisms and biomarker potential.

Main Results:

  • Numerous circRNAs have been identified in the cardiovascular system.
  • circRNAs exhibit regulatory effects via miRNA sponging and RNA-binding protein interactions.
  • circRNAs show potential as biomarkers for cardiovascular diseases.

Conclusions:

  • circRNAs play significant roles in cardiovascular development and disease pathogenesis.
  • Understanding circRNA mechanisms offers therapeutic and diagnostic opportunities.
  • Further research is needed to fully elucidate circRNA functions and applications in cardiovascular medicine.