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Related Concept Videos

siRNA - Small Interfering RNAs02:30

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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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One of the distinctive characteristics of circular shafts is their ability to maintain their cross-sectional integrity under torsion. In other words, each cross-section continues to exist as a flat, unaltered entity, simply rotating like a solid, rigid slab. To understand the distribution of shearing stress within such a shaft, consider a cylindrical section inside this circular shaft. This section has a length of L and a radius of R, with one end fixed. The radius of the cylindrical section is...
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Related Experiment Video

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Use of Alu Element Containing Minigenes to Analyze Circular RNAs
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Circular RNAs and Neuronal Development.

Lena Constantin1

  • 1Faculty of Medicine, School of Biomedical Sciences, The University of Queensland, St Lucia, 4072, QLD, Australia. l.constantin@uq.edu.au.

Advances in Experimental Medicine and Biology
|September 28, 2018
PubMed
Summary
This summary is machine-generated.

Circular RNAs (circRNAs) are abundant in the brain and play key roles in neuronal development. Research shows their involvement in synaptic function, aging, and repair within the central nervous system.

Keywords:
AgeingAlzheimer’s diseaseBrainCircular RNAIschemic strokeSynapse

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Related Experiment Videos

Last Updated: Feb 4, 2026

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Area of Science:

  • Neuroscience
  • Molecular Biology
  • Genetics

Background:

  • Circular RNAs (circRNAs) are prevalent in the brain.
  • Their expression patterns correlate with critical developmental stages in the central nervous system (CNS).

Purpose of the Study:

  • To review current research on the functions of circRNAs in neuronal development.
  • To explore the roles of circRNAs in synaptic function, aging, and repair.

Main Methods:

  • Literature review of studies on circRNA function in the brain.
  • Analysis of research on circRNA expression during neuronal development and aging.

Main Results:

  • circRNAs are enriched in synapses, suggesting a role in synaptic function and potentially synaptopathologies.
  • Neural circRNAs accumulate with age and may promote neuronal repair.

Conclusions:

  • circRNAs are significant molecules in the CNS with diverse roles in neuronal development, function, and aging.
  • Further research is needed to fully elucidate the functions of circRNAs in the brain.