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Smoking habit modulates peri-implant microbiome: A case-control study
Suzana P Pimentel1, Melline Fontes2, Fernanda V Ribeiro1
1Dental Research Division, School of Dentistry, Paulista University, São Paulo, SP, Brazil.
Journal of Periodontal Research
|September 28, 2018
Summary
Even in healthy conditions, smoking alters the peri-implant microbiome. Smokers exhibit a disease-associated microbial profile around implants, unlike non-smokers.
Area of Science:
- Oral microbiology
- Implant dentistry
- Microbiome research
Background:
- Smoking is a known risk factor for peri-implant diseases, causing microbiological shifts.
- The impact of smoking on the microbiome of healthy peri-implant tissues remains largely unknown.
Purpose of the Study:
- To investigate the peri-implant microbiome in smokers with clinically healthy peri-implant conditions.
- To compare the microbial profiles of smokers and non-smokers with healthy implants.
Main Methods:
- Collected peri-implant biofilm from healthy implants in 12 smokers (SMK) and 12 non-smokers (NSMK).
- Isolated bacterial DNA and sequenced 16S ribosomal RNA gene V3-V4 regions using pyrosequencing.
- Processed data with Quantitative Insights into Microbial Ecology, Greengenes, and Human Oral Microbiome Database.
Main Results:
- Significant differences observed in the peri-implant microbiome between SMK and NSMK groups, even in healthy states.
- SMK group showed abundance of Fusobacterium, Tannerella, and Mogibacterium.
- NSMK group showed abundance of Actinomyces, Capnocytophaga, and Streptococcus, associated with periodontal health.
Conclusions:
- Smoking negatively impacts the peri-implant microbiome.
- Even in healthy individuals, smoking promotes a disease-associated microbial state around implants.
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