Related Experiment Video
Updated: Feb 4, 2026
10:44
A Three-dimensional Thymic Culture System to Generate Murine Induced Pluripotent Stem Cell-derived Tumor Antigen-specific Thymic Emigrants
Published on: August 9, 2019
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Primary Thymic Signet Ring Cell Adenocarcinoma: A Currently Unrecognized Variant
Richard Benedict Supan Roxas1, Marie Christine Fajatin Bernardo1, Araceli Pacis Jacoba1
11 Quirino Memorial Medical Center, Manila, Philippines.
International Journal of Surgical Pathology
|September 28, 2018
Summary
This report details the first documented case of primary thymic adenocarcinoma exhibiting signet ring cell features. This rare thymic cancer variant expands the known subtypes of thymic adenocarcinoma.
Area of Science:
- Oncology
- Pathology
Background:
- Primary thymic adenocarcinoma is a rare malignancy.
- Signet ring cell morphology is uncommon in thymic tumors.
Observation:
- A 39-year-old male presented with a large anterior mediastinal mass, confirmed as primary thymic origin.
- Histopathological examination revealed neoplastic cells with signet ring features in a sclerotic stroma.
- Immunohistochemical analysis showed tumor cell reactivity for CK7, CEA, and CD5, with negativity for other markers.
Findings:
- This case represents the first reported instance of primary thymic adenocarcinoma with signet ring cell morphology.
- CD5 immunoreactivity supported the thymic origin, differentiating it from metastatic disease.
- Genetic testing for ALK, RET, and ROS1 alterations was negative.
Implications:
- This finding broadens the morphological spectrum of thymic adenocarcinoma.
- Recognizing this rare variant is crucial for accurate diagnosis and appropriate clinical management of mediastinal tumors.
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