Related Experiment Video
Updated: Feb 4, 2026

Production of Extracellular Matrix Fibers via Sacrificial Hollow Fiber Membrane Cell Culture
Published on: February 2, 2019
Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype
Lindsey T Saldin1,2, Shil Patel2, Li Zhang2
11 Department of Bioengineering, University of Pittsburgh, Pittsburgh, Pennsylvania.
Impact Statement:
Extracellular matrix (ECM) biomaterials were used to treat esophageal cancer patients after cancer resection and promoted regrowth of normal mucosa without recurrence of cancer. The present study investigates the mechanisms by which these materials were successful to prevent the cancerous phenotype. ECM downregulated neoplastic esophageal cell function (proliferation, metabolism), but normal esophageal epithelial cells were unaffected in vitro, and suggests a molecular basis (downregulation of PI3K-Akt, cell cycle) for the promising clinical results. The therapeutic effect appeared to be enhanced using homologous esophageal ECM. This study suggests that ECM can be further investigated to treat cancer patients after resection or in combination with targeted therapy.
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