[Ductal carcinoma in situ]
Marica Skaar1, Linnea Langhans, Birgitte Mertz
1niels.kroman@regionh.dk.
Abstract:
Ductal carcinoma in situ (DCIS) is a premalignant lesion in the breast. It is often asymptomatic and diagnosed by screening mammography. DCIS is treated in line with low-risk invasive breast cancer including mastectomy or breast-conserving treatment plus radiotherapy, implicating a risk of both physical and psychological side effects. Since only a part of DCIS lesions develop into invasive cancer, some women suffer from overtreatment. However, it remains yet to be identified, in which subgroup of women with DCIS treatment can safely be omitted. We need to know more about the natural course of DCIS and develop tools to tailor treatment individually.
Related Concept Videos
In-situ Hybridization
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
FISH - Fluorescent In-situ Hybridization
Methods for Studying Drug Absorption: In situ
The Doluisio method involves perfusing a prepared segment of a rat's small intestine with a solution of radiolabeled drug and a non-absorbable marker. This helps to differentiate between absorbed and non-absorbed drug concentrations. The intestinal segment is connected at both ends using tubing and syringes,...
Chromatin Position Affects Gene Expression
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...


