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Related Experiment Video

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A Standardized Method for the Analysis of Liver Sinusoidal Endothelial Cells and Their Fenestrations by Scanning Electron Microscopy

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Published on: April 30, 2015

Effects of aging on liver microcirculatory function and sinusoidal phenotype.

Raquel Maeso-Díaz¹, Martí Ortega-Ribera¹, Anabel Fernández-Iglesias^1,2

¹Liver Vascular Biology Research Group, Barcelona Hepatic Hemodynamic Laboratory, IDIBAPS Biomedical Research Institute, University of Barcelona Medical School, Barcelona, Spain.

|September 28, 2018

Summary

Healthy aging impairs liver function and microcirculation, increasing resistance and pressure. This age-related liver sinusoidal deregulation affects endothelial cells, macrophages, and stellate cells, impacting overall liver health.

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Isolation and Characterization of Mouse Primary Liver Sinusoidal Endothelial Cells

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Published on: December 16, 2021

Area of Science:

Hepatology
Gerontology
Vascular Biology

Background:

Global population median age is increasing due to medical advancements.
Aging's systemic effects are known, but liver function and microcirculation in the elderly are understudied.

Purpose of the Study:

Characterize the aged liver phenotype in healthy aging rats.
Focus on microcirculatory function and molecular changes in hepatic sinusoidal cells.
Validate findings in human liver samples.

Main Methods:

Utilized a rat model of healthy aging.
Analyzed molecular and functional status of hepatic sinusoidal cells (endothelial cells, macrophages, stellate cells).
Compared aged and young human liver tissues.

Main Results:

Healthy aging causes hepatic and sinusoidal dysfunction, marked by elevated hepatic vascular resistance and portal pressure.
Aging alters molecular profiles of sinusoidal cells: dysfunctional endothelial cells, proinflammatory macrophages, and activated stellate cells.
Key sinusoidal marker changes were confirmed in aged human livers.

Conclusions:

Aging is associated with significant liver sinusoidal deregulation.
This deregulation contributes to hepatic and sinusoidal dysfunction.
Aged livers exhibit increased vulnerability to acute and chronic injuries.