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Structure and function of the epididymis.

M J Cosentino, A T Cockett

    Urological Research
    |January 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Spermatozoa mature during epididymal transit, gaining the ability to fertilize ova. Understanding these changes in sperm maturation could lead to treatments for male infertility and new male contraceptives.

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    Area of Science:

    • Reproductive Biology
    • Andrology
    • Sperm Physiology

    Background:

    • Testicular spermatozoa are functionally immature and cannot fertilize ova.
    • Spermatozoa undergo significant changes during epididymal transit, a process known as sperm maturation.

    Purpose of the Study:

    • To review the structure and function of the mammalian epididymis.
    • To emphasize factors regulating sperm maturation during epididymal transit.

    Main Methods:

    • Review of existing literature on sperm maturation and epididymal function.
    • Analysis of morphological, motility, chemical, permeability, density, and metabolic changes in spermatozoa.

    Main Results:

    • Epididymal transit is crucial for spermatozoa to acquire fertilizing capacity.

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  • Maturation involves complex changes in sperm characteristics, though mechanisms remain incompletely understood.

    • Conclusions:

    • Understanding sperm maturation mechanisms in the epididymis is key for treating male infertility (e.g., necrospermia, low motility, ovum penetration defects).
    • The epididymis is a promising target for developing novel male contraceptive strategies.