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Updated: Feb 4, 2026

Nuclear Migration in the Drosophila Oocyte
Published on: May 13, 2021
Recapitulation of molecular regulators of nuclear motion during cell migration
Alexandra Sneider1, Jungwon Hah2, Denis Wirtz1
1a Department of Chemical and Biomolecular Engineering , Johns Hopkins University , Baltimore , MD , USA.
Abstract:
Cell migration is a highly orchestrated cellular event that involves physical interactions of diverse subcellular components. The nucleus as the largest and stiffest organelle in the cell not only maintains genetic functionality, but also actively changes its morphology and translocates through dynamic formation of nucleus-bound contractile stress fibers. Nuclear motion is an active and essential process for successful cell migration and nucleus self-repairs in response to compression and extension forces in complex cell microenvironment. This review recapitulates molecular regulators that are crucial for nuclear motility during cell migration and highlights recent advances in nuclear deformation-mediated rupture and repair processes in a migrating cell.
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