Related Experiment Video

Updated: Feb 4, 2026

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice
09:01

Non-invasive Assessment of the Efficacy of New Therapeutics for Intestinal Pathologies Using Serial Endoscopic Imaging of Live Mice

Published on: March 10, 2015

10.5K

Primary Nocturnal Enuresis: A Novel Therapeutic Strategy With Higher Efficacy

Michel Jabbour1, Rawad Abou Zahr1, Marielle Boustany2

  • 1University of Balamand, Saint George Hospital University Medical Center, Division of Urology, Beirut 1100 2807, Lebanon.

Urology
|September 28, 2018
PubMed

Insights

A new protocol combining desmopressin and propiverine significantly improved treatment success and reduced relapse rates for children with primary nocturnal enuresis. This approach offers higher efficacy and better long-term outcomes for bedwetting management.

Area of Science:

  • Pediatrics
  • Urology
  • Clinical Pharmacology

Background:

  • Primary nocturnal enuresis affects a significant number of children, impacting their quality of life.
  • Existing treatments for nocturnal enuresis have varying efficacy and relapse rates.
  • A need exists for optimized treatment protocols to enhance outcomes.

Purpose of the Study:

  • To introduce and evaluate a novel treatment protocol for primary nocturnal enuresis.
  • The objective was to increase treatment efficacy and decrease the rate of relapse.
  • To assess the effectiveness of a combination therapy approach.

Main Methods:

  • A prospective study involving 185 children diagnosed with nocturnal enuresis (age >5 years).
  • Participants received a combination therapy of desmopressin (120 µg MELT) and propiverine (7.5 mg), with dosage adjustments based on response.
  • Outcomes were assessed using International Children Continence Society (ICCS) definitions over a mean follow-up of 62 months.

Main Results:

  • One hundred twenty-two patients met inclusion criteria, with a median age of 9 years.
  • The protocol achieved an 87% complete success rate, with a 13% failure and relapse rate.
  • Higher success rates (92.7%) were observed with 120 µg desmopressin maintenance therapy compared to higher doses (65%).

Conclusions:

  • Combination therapy with a structured withdrawal protocol demonstrates superior efficacy in treating primary nocturnal enuresis.
  • This protocol leads to higher success rates and reduced relapse in pediatric patients.
  • The findings support the adoption of this structured combination therapy for improved bedwetting management.
Abstract

More Related Videos

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics08:29

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Published on: October 2, 2014

15.2K
High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies09:19

High Throughput Characterization of Adult Stem Cells Engineered for Delivery of Therapeutic Factors for Neuroprotective Strategies

Published on: January 4, 2015

11.2K

Related Concept Videos

Self-Efficacy01:29

Self-Efficacy

Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
230
Therapeutic Index01:13

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...
6.8K
Therapeutic Communication01:30

Therapeutic Communication

Communication is a lifelong learning process. Through therapeutic communication, nurses can collect relevant assessment data, provide education and counseling, and interact during nursing interventions. Sending and receiving messages occur through verbal and nonverbal communication techniques and can happen separately or simultaneously.
Verbal communication depends on language or a prescribed way of using words so that people can share information effectively. The critical aspects of verbal...
8.2K
Persuasion Strategies01:52

Persuasion Strategies

Researchers have tested many persuasion strategies, including the foot-in-the door and the door-in-the-face techniques, in a variety of contexts. Ultimately, the principles are effective in selling products and changing people’s attitude, ideas, and behaviors (Cialdini & Goldstein, 2004).
43.5K
Cholinergic Antagonists: Therapeutic Uses01:26

Cholinergic Antagonists: Therapeutic Uses

Antimuscarinic drugs have various therapeutic applications by inhibiting parasympathetic stimulation in different systems. Here are the key therapeutic uses of antimuscarinics:    
Respiratory Tract: Ipratropium, aclidinium, and tiotropium treat asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). They protect against bronchoconstriction caused by irritants like cigarette smoke, sulfur dioxide, and ozone. They also help reduce nasopharyngeal...
1.5K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1.1K