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Effects of a cluster-randomized school-based prevention program on physical activity and microvascular function
Monika Siegrist1, Henner Hanssen2, Christoph Lammel1
1Department of Prevention, Rehabilitation and Sports Medicine, Technical University of Munich, Klinikum Rechts der Isar, Munich, Germany.
Atherosclerosis
|September 28, 2018
Summary
The JuvenTUM 3 school program boosted children's physical activity and improved retinal microvascular function, showing promise for early cardiovascular disease prevention.
Area of Science:
- Pediatric vascular health
- Preventive cardiology
- Lifestyle interventions in children
Background:
- The impact of school-based programs on children's microvascular health is not well understood.
- Early detection and prevention of vascular dysfunction are crucial for long-term cardiovascular health.
- Lifestyle factors significantly influence vascular health from a young age.
Purpose of the Study:
- To evaluate the effectiveness of the JuvenTUM 3 school-based lifestyle intervention program.
- To assess the program's impact on physical activity, fitness, biomarkers, and microvascular function in children.
- To determine if the intervention improves early markers of vascular dysfunction.
Main Methods:
- A cluster-randomized trial involving 434 children aged 10-11 years over 18 months.
- Intervention group received weekly lifestyle lessons promoting physical activity and healthy behaviors.
- Microvascular function assessed using retinal vessel analysis (CRAE, CRVE, AVR); physical activity via questionnaire.
Main Results:
- School-based physical activity significantly increased in the intervention group (41% vs 19%).
- Improvements observed in arteriolar-to-venular diameter ratio (AVR) and retinal venular diameter (CRVE) in the intervention group.
- Positive vascular effects, including for CRAE and AVR, were noted in overweight children within the intervention group.
Conclusions:
- The JuvenTUM 3 program effectively increased school-based physical activity.
- The intervention led to favorable changes in retinal microvasculature function, an early indicator of vascular health.
- These findings support early lifestyle interventions for the primary prevention of cardiovascular disease in children.
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