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Related Concept Videos

Larynx01:21

Larynx

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The human larynx, often referred to as the voice box, is an intricate organ located in the neck. It serves as a pathway for air to enter the lungs during respiration and is an essential component of voice production.
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One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
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Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
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Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
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Related Experiment Video

Updated: Feb 4, 2026

Vessel-sparing Excision and Primary Anastomosis
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Development of Excised Larynx.

Rong Luo1, Weijia Kong1, Xin Wei2

  • 1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Journal of Voice : Official Journal of the Voice Foundation
|September 29, 2018
PubMed
Summary
This summary is machine-generated.

Research on excised larynges has advanced laryngeal function studies over 5 years. These methods, combined with animal models, aid in understanding and treating laryngeal disorders.

Keywords:
Biomechanical PropertiesClinical ApplicationsExcised larynxLaryngoplastyPhonation

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Area of Science:

  • Laryngology
  • Bioengineering
  • Speech Science

Background:

  • The larynx is crucial for phonation, breathing, and swallowing.
  • In vivo studies offer relevance but require invasive measurements.
  • Excised larynx research provides a controlled environment for studying laryngeal functions.

Purpose of the Study:

  • To review the progress of excised larynx research over the past 5 years.
  • To highlight the application of excised larynx findings to clinical treatments.
  • To emphasize the integration of excised larynx studies with other research methodologies.

Main Methods:

  • Review of research on excised larynges published in the last 5 years.
  • Analysis of the evolution of methodologies and applications.
  • Synthesis of findings from excised larynx studies, animal models, and clinical observations.

Main Results:

  • Increased use of animal models in conjunction with excised larynx research.
  • Application of excised larynx study concepts to develop treatment methods for laryngeal disorders.
  • Advancements in understanding laryngeal anatomy, imaging, and biomechanical properties.

Conclusions:

  • Excised larynx studies have significantly contributed to laryngeal research over the past 5 years.
  • These studies are increasingly informing treatment strategies for laryngeal conditions.
  • Continued integration with animal experimentation and clinical data is essential for validating excised larynx findings.