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Oral Biofilm Sampling for Microbiome Analysis in Healthy Children
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Moody microbiome: Challenges and chances.

Po-Hsiu Kuo1, Yu-Chu Ella Chung1

  • 1Department of Public Health & Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan.

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Summary

The gut microbiome influences brain development and function, with its imbalance linked to mood disorders. Probiotics show promise in alleviating depressive symptoms and improving well-being.

Keywords:
Bipolar disorderDepressionGene–microbiome interactionGut-brain axisManiaMicrobiotaProbiotics

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Area of Science:

  • Neuroscience
  • Microbiology
  • Psychiatry

Background:

  • The gut microbiome plays a crucial role in central nervous system development and function.
  • Dysfunction of the microbiota-gut-brain axis is associated with neuropsychiatric disorders and depression.

Purpose of the Study:

  • To review current evidence on microbiota studies in human clinical samples, focusing on affective disorders.
  • To evaluate the efficacy of probiotics and antibiotics in managing mood symptoms.

Main Methods:

  • Review of clinical trials examining probiotic supplementation (with or without antidepressants) and adjuvant antibiotic treatments.
  • Analysis of human clinical samples to understand microbiota's role in mood disorders.

Main Results:

  • Clinical trial results suggest probiotics can alleviate depressive symptoms and enhance well-being.
  • Antibiotic-induced gut microbiota modification may serve as an effective adjuvant therapy for depression.

Conclusions:

  • The precise role of gut microbiota in depression and mania requires further elucidation.
  • Modulating gut microbiota composition presents a potential therapeutic strategy for mood disorders.