Related Experiment Video
Updated: Feb 4, 2026

An In Vitro Dissolution Determination of Multi-Index Components in Tibetan Medicine Rhodiola Granules
Published on: November 4, 2022
Effect of ultrasound on dissolution of Al in Sn
Yun Liu1, Weiyuan Yu1, Yingzong Liu1
1Lanzhou University of Technology, State Key Laboratory of Gansu Province, Advanced Processing and Recycling of Nonferrous Metals, Lanzhou 730050, Gansu Province, PR China.
Abstract:
This study investigated the dissolution behavior of the aluminum substrate in molten tin at 523 K, 573 K, and 623 K with and without applied ultrasonic vibration (USV) respectively. In order to reveal the mechanism of accelerated dissolution by USV, the ultrasonic pressure distribution in the molten pool and the cavitation thermal effect were simulated by finite element analysis. Furthermore, the microstructures after the dissolution were observed. The results showed USV greatly accelerated the dissolution rate (by 21-27 times) at the interface, where an uneven ultrasonic pressure distribution in the molten pool caused inhomogeneous dissolution. The amount of Al dissolved in Sn at a particular temperature after 5 s of USV was equivalent to a holding time of 30 min without USV. The simulation results showed that the cavitation-thermal effect caused by USV increased the temperature (up to the melting point of Al) at the interfacial micro-region. It is evident that the combined effect of cavitation-thermal and ultrasonic streaming caused by USV increase the dissolution rate.
More Related Videos
05:50International Expert Consensus and Recommendations for Neonatal Pneumothorax Ultrasound Diagnosis and Ultrasound-guided Thoracentesis Procedure
Published on: March 12, 2020
09:59Coherent anti-Stokes Raman Scattering CARS Microscopy Visualizes Pharmaceutical Tablets During Dissolution
Published on: July 4, 2014
Related Concept Videos
Ultrasound II: Endoscopic Ultrasound and FibroScan
Endoscopic Ultrasound (EUS):
In Vitro Drug Dissolution: Alternative Methods
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Factors Affecting Dissolution: Polymorphism, Amorphism and Pseudopolymorphism
Some polymorphic crystals possess lower aqueous solubility than their amorphous counterparts, leading to incomplete absorption. For instance, the oral suspension of Chloramphenicol, which...
Factors Affecting Dissolution: Drug pKa, Lipophilicity and GI pH
A drug's pKa and the pH of the gastrointestinal (GI) tract play crucial roles...
Drug Dissolution: Requirements and Profile Comparison