Selenium inadequacy hampers thyroid response of young children after iodine repletion

Selenium (Se) is an integral component of iodothyronine deiodinase, glutathione peroxidase and thioredoxin reductase enzymes and thus is important for normal thyroid function. This study investigated the influence of Se inadequacy on thyroid response of iodine-replete young children. Serum thyroxine (T₄), triiodothyronine (T₃), thyroglobulin (Tg), thyroid stimulating hormone (TSH), and Se were analyzed in 54-60 mo old children (n = 628) from the Amhara region of Ethiopia before salt iodization was commenced; analyses were repeated (n = 555) 15 mo after iodized salt became available. Iodized salt coverage increased from 12.2% to 91.6% of households. Median urinary iodine concentration (UIC) among children increased from 9 μg/l to 167 μg/l (p < 0.001). In addition, all thyroid indices except T₃ showed significant improvement (p < 0.05). Nearly, half of the study children (49.1%) had Se inadequacy (serum Se < 70 μg/l). Serum Se was significantly correlated with T₃ (r = 0.38, p < 0.001), T₄ (r = 0.15, p < 0.001), TSH (r=-0.205, p < 0.001) and Tg (r= -0.11, p < 0.01) concentrations 15 mo after iodine repletion; baseline serum Se and T₄(r= -0.22, p < 0.01) were inversely correlated. Despite adequate iodine status, children with low serum Se had lower serum T₄ (p = 0.003) and T₃(p < 0.001) but higher TSH concentration (p = 0.003). In the partial least square regression model, Se was among the latent variables significantly explaining T₄ and T₃. Results of the present study suggest that Se inadequacy negatively affects the thyroid metabolism of iodine-replete children and may present a substantial public health concern thus emphasize the need to consider correction of Se status for normal thyroid function as well as for benefits from its diverse biological roles.