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Iodine density Changes in Hepatic and Splenic Parenchyma in Liver Cirrhosis with Dual Energy CT (DECT): A Preliminary

Jian Dong1, Fuliang He2, Lei Wang2

  • 1Department of Radiology, Beijing Shijitan Hospital, Capital Medical University, No. 10 Tieyi St, Haidian District, Beijing 100038, China.

Academic Radiology
|September 29, 2018
PubMed

Insights

Dual-energy CT (DECT) can assess hemodynamic changes in liver cirrhosis by measuring iodine density. Specific iodine density metrics correlate with Child-Pugh grade, suggesting DECT

Area of Science:

  • Radiology
  • Medical Imaging
  • Hepatology

Background:

  • Liver cirrhosis significantly alters hepatic and splenic hemodynamics.
  • Accurate assessment of these hemodynamic changes is crucial for patient management.
  • Dual-energy CT (DECT) offers advanced imaging capabilities for quantitative analysis.

Purpose of the Study:

  • To investigate hemodynamic alterations in liver cirrhosis using DECT.
  • To compare iodine density in hepatic and splenic parenchyma between cirrhotic patients and healthy controls.
  • To correlate quantitative iodine density metrics with Child-Pugh grades in liver cirrhosis.

Main Methods:

  • Forty-six liver cirrhosis patients and 22 healthy volunteers underwent contrast-enhanced DECT.
  • Iodine density (ID) was measured in hepatic and splenic parenchyma and portal vein.
  • Quantitative indices including normalized ID of liver (NIDLAP) and arterial iodine density fraction (AIF) were calculated and correlated with Child-Pugh grade.

Main Results:

  • Liver cirrhosis patients exhibited higher NIDLAP, IDSVP, IDPVP, and AIF, and lower NIDSAP compared to controls.
  • NIDLAP, AIF, IDSVP, and IDPVP were significantly lower in Child-Pugh Grade A compared to Grades B and C.
  • AIF (R=0.71) and NIDLAP (R=0.46) showed a positive correlation with Child-Pugh grade.

Conclusions:

  • DECT-based iodine density measurements effectively reveal hemodynamic changes in liver and spleen in cirrhosis.
  • Quantitative indices AIF and NIDLAP correlate with liver cirrhosis severity (Child-Pugh grade).
  • DECT shows potential as a noninvasive tool for assessing liver cirrhosis severity.
Abstract

Keywords:
X-raycomputed tomographydual energyiodine densityliver cirrhosis

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