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Updated: Feb 4, 2026

Minced Tissue in Compressed Collagen: A Cell-containing Biotransplant for Single-staged Reconstructive Repair
Published on: February 24, 2016
Structured care to improve outcomes in primary single stage laryngotracheal reconstruction
Prasad John Thottam1, Matthew Georg2, Jeffrey P Simons2
1Beaumont Children's Hospital, Department of Pediatric Otolaryngology, Head and Neck Surgery, Royal Oak, MI, USA; Michigan Pediatric Ear, Nose and Throat Associates, West Bloomfield, MI, USA; Children's Hospital of Pittsburgh of UPMC, Department of Pediatric Otolaryngology, Head and Neck Surgery, Pittsburgh, PA, USA.
Purpose:
To examine single stage laryngotracheal reconstruction (SSLTR) care to reduce complication and failure rate.
Methods:
Forty-five patients that underwent primary SSLTR were examined retrospectively. All had pre-operative direct laryngoscopy and bronchoscopy, esophagoscopy with biopsy and MRSA screening. Pre-operative subglottic stenosis (SGS) grade and associated comorbidities were recorded. Intraoperative graft location and type was documented. Hospital course and results were evaluated and compared to cited literature.
Results:
The median age at reconstruction was 2 years (0-15 years). 42.2% were male. 66.7% had gastroesophageal disease and 24.4% a MRSA history. Grade 2 SGS was noted pre-operatively in 37.8% and grade 3 or 4 in 57.7% of patients. Post-surgical hospital course was examined. 77.8% of patients were extubated on planned date. 95.6% of patients had operation specific successful decannulation. Graft type and variations of graft placement as well as MRSA and GERD status didn't affect procedure success rate. Active GERD was related to failure of extubation on planned day (p = 0.02). An abnormal pre-operative swallowing examination was associated with higher complication rates (p = 0.03).
Conclusion:
Utilizing a more structured approach to SSLTR work-up and addressing potential SSLTR pitfalls may result in higher operation specific decannulation rates. Pre-operative GERD and swallowing dysfunction were associated with higher rates of adverse events.
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