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Biomarker-driven targeted therapies for gastric/gastro-esophageal junction malignancies

Salem Kim1, Afsaneh Barzi2, Lakshmi Rajdev1

  • 1Department of Oncology, Montefiore Medical Center/Albert Einstein College of Medicine, Bronx, NY.

Seminars in Oncology
|September 29, 2018
PubMed

Insights

Advanced gastric and gastroesophageal cancers exhibit aggressive traits and drug resistance. This review explores recent progress in targeted therapies for these challenging malignancies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Genetics

Background:

  • Gastroesophageal malignancies are characterized by significant genetic and molecular alterations.
  • These alterations contribute to aggressive disease progression, rapid metastasis, and early drug resistance.
  • Many patients present with advanced or metastatic disease requiring systemic treatment.

Purpose of the Study:

  • To review recent advancements in targeted therapy development for advanced gastric and gastroesophageal cancer.
  • To highlight novel therapeutic strategies beyond traditional chemotherapy.

Main Methods:

  • Literature review of recent studies and clinical trials.
  • Analysis of emerging targeted therapies and their mechanisms of action.
  • Synthesis of data on targeted agents for advanced gastric and gastroesophageal cancer.

Main Results:

  • Identification of several promising targeted therapies currently in development or clinical use.
  • Discussion of specific molecular targets and associated drug candidates.
  • Overview of the potential impact of targeted therapies on patient outcomes.

Conclusions:

  • Targeted therapies represent a significant advancement in treating advanced gastric and gastroesophageal cancers.
  • Further research and clinical trials are crucial to optimize the use of these novel agents.
  • Personalized medicine approaches hold promise for improving treatment efficacy and patient survival.
Keywords:
Gastric adenocarcinomaGastric cancerGastroesophageal adenocarcinoma

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