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Thrombin lag time is increased in children with mild asthma
B T Koksal1, I Eker2, N Y Ozbek3
1Department of Pediatric Allergy, Baskent University, Faculty of Medicine, Ankara, Turkey.
Insights
Mild asthma in children may alter coagulation, specifically affecting thrombin generation initiation. This study found longer thrombin lag times in children with mild asthma compared to healthy controls.
Area of Science:
- Pediatric Pulmonology
- Hemostasis and Thrombosis
- Inflammatory Diseases
Background:
- Inflammation and coagulation pathways are interconnected.
- Thrombin, a key coagulation enzyme, plays a role in inflammatory processes.
Purpose of the Study:
- To investigate thrombin generation dynamics in pediatric patients diagnosed with mild asthma.
Main Methods:
- Compared thrombin generation tests (TGT) using calibrated automated thrombogram (CAT) in 42 children with mild asthma and 49 healthy children.
- Assessed endogenous thrombin potentials, peak thrombin, thrombin lag time, and time to peak.
Main Results:
- Children with mild asthma exhibited significantly longer thrombin lag times (3.98±1.2 min) versus controls (3.29±0.6 min).
- A longer thrombin tail time was observed in asthmatic children (19.5±8.9 min) compared to controls (16.7±2.9 min).
- Thrombin peak and lag time showed inverse correlations with FEF 25-75, a measure of airflow obstruction.
Conclusions:
- Mild asthma in children appears to influence coagulation, potentially by affecting the initiation phase of thrombin generation.
- The observed coagulation disturbances in mild asthma may not elevate overall thrombin levels significantly.
Background:
Inflammation and coagulation are closely linked events. Thrombin is the key enzyme in coagulation system and also has roles in inflammation.
Objective:
The aim of our study was to evaluate thrombin generation in children with mild asthma.
Methods:
Forty-two children with mild asthma and 49 healthy children were included in the study. All patients performed spirometry. Thrombin generation tests (TGT) were performed with a calibrated automated thrombogram (CAT) in children without asthma exacerbation during the last six months. During CAT assay thrombogram curves were obtained. The area under the curve showed endogenous thrombin potentials and indicated the total amount of endogenous thrombin generated; the peak height showed the highest thrombin value, thrombin lag time and time to thrombin peak were measured.
Results:
Thrombin lag time was significantly longer in children with asthma (3.98±1.2min) compared to those in the control group (3.29±0.6min) (p<0.01). Children with asthma also had longer thrombin tail time compared to the control group (19.5±8.9min vs. 16.7±2.9min, p=0.02). Thrombin peak was inversely correlated with FEF 25-75 (r=-0.41, p<0.01). Thrombin lag time was inversely correlated with FEF 25-75 (r=-0.39, p<0.01).
Conclusion:
Inflammation in mild asthma seems to disturb coagulation but this disturbance may not be so strong as to increase thrombin levels and may only affect the initiation phase of thrombin generation.
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