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Refined Murine Model of Idiopathic Pulmonary Fibrosis
Published on: June 17, 2025
Idiopathic macrocheilia
Haren Pandya1, Hiren Dharmendrabhai Patel2, Jigar Mayankbhai Purani3
1Oral and Maxillofacial Surgery, Dharmsinh Desai University Faculty of Dental Science, Nadiad, Gujarat, India.
Idiopathic macrocheilia, a rare condition causing lip swelling, was diagnosed in a 13-year-old boy. Treatment with intralesional triamcinolone acetonide effectively reduced swelling, with no recurrence observed during follow-up.
Area of Science:
- Oral Medicine
- Dermatology
- Pathology
Background:
- Macrocheilia, characterized by lip enlargement, presents diagnostic challenges.
- Differential diagnosis includes orofacial granulomatosis and infections.
- Idiopathic macrocheilia requires exclusion of other pathologies.
Observation:
- A 13-year-old boy presented with painless bilateral lip swelling and gingival enlargement.
- Clinical presentation mimicked orofacial granulomatosis.
- Histopathology revealed chronic non-specific infection.
Findings:
- Diagnosis of idiopathic macrocheilia was established by exclusion.
- Intralesional triamcinolone acetonide (40 mg twice weekly for 3 weeks) was administered.
- Significant remission of lip swelling was achieved.
Implications:
- This case highlights the importance of a thorough exclusion process for diagnosing idiopathic macrocheilia.
- Intralesional corticosteroid injection offers a potential treatment modality for idiopathic macrocheilia.
- Successful management suggests a favorable prognosis with appropriate intervention.
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