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Related Concept Videos

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
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Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

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Allergic rhinitis.

Peter Small1, Paul K Keith2, Harold Kim2,3

  • 11Division of Allergy & Clinical Immunology, Sir Mortimer B. Davis Jewish General Hospital, Montreal, QC Canada.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|September 29, 2018
PubMed
Summary
This summary is machine-generated.

Allergic rhinitis, a common condition causing nasal symptoms, often goes undiagnosed. Effective treatments include antihistamines, nasal steroids, and allergen immunotherapy for persistent cases.

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Area of Science:

  • Immunology
  • Otolaryngology
  • Allergy & Clinical Immunology

Background:

  • Allergic rhinitis is a prevalent chronic condition frequently associated with asthma and conjunctivitis.
  • It often remains undiagnosed in primary care despite classic symptoms like nasal congestion, itch, rhinorrhea, and sneezing.

Purpose of the Study:

  • To provide a comprehensive overview of the pathophysiology, diagnosis, and management of allergic rhinitis.
  • To highlight the importance of early diagnosis and appropriate treatment strategies.

Main Methods:

  • Review of current literature on allergic rhinitis.
  • Emphasis on diagnostic methods including patient history, physical examination, and allergen skin testing.
  • Discussion of pharmacologic and immunotherapeutic treatment options.

Main Results:

  • Diagnosis relies on a combination of clinical presentation and objective testing.
  • Second-generation antihistamines and intranasal corticosteroids are primary treatments.
  • Allergen immunotherapy offers an effective alternative for refractory or patient-preferred cases.

Conclusions:

  • Allergic rhinitis requires thorough evaluation for accurate diagnosis.
  • A stepwise approach to management, including pharmacotherapy and immunotherapy, is crucial.
  • Understanding the pathophysiology aids in optimizing patient care and outcomes.