Related Experiment Video
Updated: Feb 4, 2026

Restraint to Induce Stress in Mice and Rats
Published on: December 6, 2024
Anti-stress activity of Sargassum polycystum extracts using a cold restraint stress model
Radipta Lailatussifa1, Amir Husni1, Agung Endro Nugroho2
1Department of Fisheries Faculty of Agriculture Universitas Gadjah Mada, Jalan Flora Gedung A4 Bulaksumur, Yogyakarta, 55281 Indonesia.
Abstract:
Anti-stress effects of polyphenol extracts of Sargassum polycystum were evaluated. Polyphenol extracts of S. polycystum and diazepam were compared for anti-stress activities using a cold restraint animal stress model. S. polycystum extracts were administered orally at dosages of 150 and 450 mg/kg. Diazepam, an anti-stress agent, was used as a standard drug at 0.18 mg/kg p.o. Both dosages of S. polycystum extracts showed good anti-stress effects. Due to cold restraint stress there was an imbalance in levels of biochemical parameters, including glucose, triglycerides, cholesterol, alkaline phosphatase (ALP), alanine aminotransferase (ALT), and aspartate amino transferase (AST), which were near normalized following adminstration of S. polycystum extracts. Polyphenol extracts of S. polycystum at oral dosages of 150 and 450 mg/kg exerted anti-stress effects.
Related Concept Videos
Responses to Heat and Cold Stress
Responses to Salt Stress
Stress
General State of Stress
Specifically, consider a tetrahedral element where one face, labeled XYZ, is perpendicular to the line OA, and the remaining faces align with the coordinate axes with point O as the origin. At any point, such as point O, the stress tensor can be used to determine the stress...
Stress Prevention and Stress Management Techniques II
Type A Personality: Driven and Easily Stressed
Individuals with Type A personalities are often highly competitive and ambitious and operate with a strong sense of urgency. Commonly labeled as...
Stress Prevention and Stress Management Techniques I
Conscientiousness
Conscientious individuals tend to be organized, responsible, and disciplined. They prioritize completing tasks and following structured routines,...

