Related Experiment Video
Updated: Feb 4, 2026

Bioluminescence Imaging of Heme Oxygenase-1 Upregulation in the Gua Sha Procedure
Published on: August 28, 2009
Effect of (-)-epigallocatechin-3-gallate on anti-inflammatory response via heme oxygenase-1 induction during
12School of Food Biotechnology and Nutrition, Kyungsung University, Busan, 48434 Korea.
Abstract:
In this study, we examined the effects of (-)-epigallocatechin-3-gallate (EGCG) on anti-inflammatory responses through the induction of heme oxygenase-1 (HO-1) in cocultured macrophages and adipocytes. EGCG significantly decreased the secretion of nitric oxide (NO) and monocyte chemoattractant protein-1 in the coculture of RAW 264.7 macrophages and differentiated 3T3-L1 adipocytes. In addition, EGCG inhibited the expression of inducible nitric oxide synthase in cocultured macrophages and peroxisome proliferator-activated receptor-gamma in cocultured adipocytes. Furthermore, the HO-1 expression showed an approximately 4-fold increase in cocultured adipocytes and an approximately 6-fold increase in cocultured macrophages. Lastly, HO-1 silencing induced NO generation in cocultured cells regardless of EGCG treatment. These results indicate that EGCG inhibited inflammatory responses by suppressing the production of proinflammatory cytokines through HO-1 induction during adipocyte-macrophage interaction.
Related Concept Videos
Inflammatory Response
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
Inflammatory Response II: Inflammatory Exudate and Tissue Repair
The typical wound exudate is odorless, transparent, straw-colored, thin, and watery. Exudate, however, can differ depending on the state of wound healing. Likewise, the...
Inflammatory Response I: Vascular and Cellular
Humoral Immune Responses
Induction
A...
Self-Inductance
Consider a circuit connected to an AC source. As the current varies with time, the magnetic flux through the circuit correspondingly changes. Faraday's law tells us that an emf would...

