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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases
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Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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Data mining of micrornas in breast carcinogenesis which may be a potential target for cancer prevention

Jin-Wook Kang1,2, Min-Ji Kim1,2, Hyun-Ah Baek3

  • 11Molecular Mechanisms of Functional Foods Laboratory, Jeonju University, Jeonju, Jeonbuk, 55069 Korea.

Food Science and Biotechnology
|September 29, 2018
PubMed

Insights

MicroRNAs (miRNAs) are key regulators in breast cancer development. This study identifies specific miRNAs targeting oncogenes, offering potential for novel breast cancer prevention strategies.

Area of Science:

  • Molecular Biology
  • Genomics
  • Oncology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs that regulate gene expression post-transcriptionally.
  • Dysregulation of miRNAs is a hallmark of various cancers, including breast cancer.
  • miRNAs play critical roles in cellular processes like differentiation, cell-cycle control, and apoptosis.

Purpose of the Study:

  • To investigate the dysregulation of specific miRNAs in human breast cancer.
  • To identify miRNAs that target key breast cancer oncogenes.
  • To explore the potential of these miRNAs as targets for breast cancer prevention.

Main Methods:

  • Genomic data from The Cancer Genome Atlas (TCGA) for human breast cancer samples were analyzed.
  • IluminaGA_miRNASeq platform was utilized for miRNA expression profiling.
  • Multiple databases (mirWalk, miranda, mirDB, RNA22, TargetScan) were employed to predict and validate miRNA targets.
  • Focus was placed on miRNAs associated with known breast cancer oncogenes (e.g., C-myc, HER2, BRCA1/2).

Main Results:

  • Significant dysregulation of specific miRNAs was observed in breast cancer samples.
  • Several miRNAs were identified as potential regulators of key breast cancer oncogenes.
  • The study provides a list of relevant miRNAs targeting oncogenes like C-myc, HER2, cyclin D-1, N-RAS, FGF-4, FGF-3, BRCA1, and BRCA2.

Conclusions:

  • miRNA expression profiles are significantly altered in breast cancer.
  • Targeting specific oncogene-regulating miRNAs presents a promising avenue for breast cancer prevention.
  • Understanding miRNA functions in carcinogenesis is crucial for developing effective therapeutic strategies.
Keywords:
breast cancerchemopreventiondata miningmicroRNAtarget

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