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A Polymer-based Piezoelectric Vibration Energy Harvester with a 3D Meshed-Core Structure

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New antibacterial-core structures based on styryl quinolinium.

Eunsuk Kim¹, Seung-Heon Lee¹, Seung-Jun Lee¹

¹1Department of Molecular Science and Technology, Ajou University, Suwon, Gyeonggi, 16499 Korea.

Food Science and Biotechnology

|September 29, 2018

Summary

New quinolinium salts show potent antimicrobial activity against Gram-positive and Gram-negative bacteria. Electron-withdrawing groups enhance efficacy, and synergistic effects were observed when combined with ampicillin.

Keywords:

bacteria pathogen quinolinium resistance susceptibility

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A Robust Pneumonia Model in Immunocompetent Rodents to Evaluate Antibacterial Efficacy against S. pneumoniae, H. influenzae, K. pneumoniae, P. aeruginosa or A. baumannii

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Published on: January 2, 2017

Area of Science:

Medicinal Chemistry
Antimicrobial Agents
Organic Synthesis

Background:

Quaternary quinolinium salts are explored as alternative antimicrobial agents.
Improving existing quinolinium compounds is crucial for enhanced efficacy.
Understanding structure-activity relationships guides the development of novel antimicrobials.

Purpose of the Study:

To design and synthesize novel styryl quinolinium derivatives.
To evaluate the antibacterial activity of these derivatives against Gram-positive and Gram-negative bacteria.
To investigate the relationship between chemical structure and antimicrobial potency.

Main Methods:

Rational design of 10 styryl quinolinium derivatives with varied substituents.
Determination of minimum inhibitory concentrations (MICs) for antibacterial activity.
Assessment of synergistic effects with ampicillin.

Main Results:

Six compounds demonstrated bactericidal effects against Gram-positive bacteria (MICs: 2.4–37.5 μg/mL).
Two compounds showed activity against Gram-negative bacteria (MICs: 18.75–75 μg/mL).
Compounds with strong electron-withdrawing groups exhibited superior activity.

Conclusions:

The study provides a foundation for developing potent quinolinium-based antimicrobials.
Electron-withdrawing substituents are key for enhancing antibacterial activity.
Synergistic antimicrobial effects were observed with ampicillin co-administration.