Malassezia infections with systemic involvement: Figures and facts

Area of Science:

• Mycology
• Infectious Diseases
• Clinical Microbiology

Background:

• Malassezia yeasts are lipophilic commensals that can cause skin disease.
• Severely immunocompromised patients and preterm infants are at high risk for systemic Malassezia infections.
• Central venous catheters are common entry points for Malassezia colonization and infection.

Observation:

• Three unrelated cases of Malassezia bloodstream infection occurred at a university hospital over two years.
• Patients often present with non-specific clinical findings.
• Laboratory diagnosis can be delayed due to the need for lipid supplementation in cultures.

Findings:

• This report details three cases of Malassezia bloodstream infection.
• The study discusses clinical outcomes and compares them with existing literature.
• Key aspects covered include epidemiology, risk factors, pathogenesis, diagnosis, susceptibility, and treatment.

Implications:

• Highlights the risk of Malassezia bloodstream infections in specific patient populations.
• Emphasizes challenges in timely laboratory diagnosis.
• Provides a comprehensive review to guide clinical management and further research.