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Updated: Feb 4, 2026
Direct Drug Delivery to Kidney via the Renal Artery
Published on: April 17, 2021
The Impact of Renal Tissue Procurement at Bedside on Specimen Adequacy and Best Practices
Jacob T Wooldridge1, Amy Davis1, Wayne G Fischer2
1Department of Pathology, University of Texas Medical Branch, Galveston.
Objectives:
Renal biopsy is the gold standard for the diagnosis of both native and allograft renal diseases. We studied the impact of tissue procurement at bedside (TPB) omission on the adequacy of renal biopsies.
Methods:
We compared 120 renal biopsies collected during 2015 using TPB with 111 renal biopsies collected during 2016 when TPB was discontinued. Adequacy criteria were applied as follows: by light microscopy, 10 glomeruli and two arteries for allograft biopsies and seven glomeruli for native biopsies. At least one glomerulus was considered adequate for immunofluorescence and electron microscopy in both groups.
Results:
The rate of inadequacies in allograft biopsies increased significantly, from 12.50% to 21.61% (P < .05), when TPB was discontinued.
Conclusions:
Elimination of TPB service had a negative impact on allograft specimen adequacy. Repeat biopsies add cost and delay patient care. Institutions should take this into consideration when considering omission of TPB.
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