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The role of interleukins in preeclampsia: A comprehensive review

Ioannis Bellos1, Vasilios Karageorgiou1, Dimitrios Kapnias1

  • 1National and Kapodistrian University of Athens, Athens, Greece.

American Journal of Reproductive Immunology (New York, N.Y. : 1989)
|September 29, 2018
PubMed

Preeclampsia is a multi-system hypertensive disorder of pregnancy, with significant rates of maternal and neonatal morbidity. It represents a major cause of preterm birth, as definitive treatment demands fetal delivery. Although its pathophysiology is complicated, placental hypoxia and endothelial dysfunction constitute established pathogenetic steps of the disease. Inflammation is considered to be a crucial mediator of preeclampsia process, as an imbalance between TH 1, TH 2, and TH 17 immune responses is observed. The present review accumulates current knowledge about the contribution of interleukins in preeclampsia, summarizing the pathways through which each interleukin exerts its function in the disease. Also, the role of genetic polymorphisms is explored and the predictive efficacy of maternal serum interleukin levels is evaluated. Finally, recommendations about the safe interpretation of the outcomes, as well as guidance for future research, are provided.

Keywords:
inflammationinterleukinpreeclampsiapregnancytumor necrosis factor

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