Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Vitamins01:30

Vitamins

2.5K
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced...
2.5K
Wave Parameters01:10

Wave Parameters

9.4K
The simplest mechanical waves are associated with simple harmonic motion and repeat themselves for several cycles. These simple harmonic waves can be modeled using a combination of sine and cosine functions. Consider a simplified surface water wave that moves across the water's surface. Unlike complex ocean waves, in surface water waves, water moves vertically, oscillating up and down, whereas the disturbance of the wave moves horizontally through the medium. If a seagull is floating on the...
9.4K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

7.9K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
7.9K
Mineral, Vitamin and Water Absorption01:27

Mineral, Vitamin and Water Absorption

1.6K
Electrolytes are essential minerals and ions primarily obtained from the diet and absorbed through the gastrointestinal tract. Most electrolytes are absorbed in the small intestine. While the absorption of iron and calcium primarily occurs in the duodenum, calcium is also absorbed in the jejunum and ileum. In these regions, passive diffusion contributes to its absorption alongside active transport mechanisms in the duodenum. These ions can exit the enterocytes through specialized active...
1.6K
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

5.5K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
5.5K
Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants01:18

Anticoagulant Drugs: Vitamin K Antagonists and Direct Oral Anticoagulants

2.4K
Oral anticoagulants are vital tools in preventing and treating blood clotting disorders. This diverse class of medications can be categorized as vitamin K antagonists, exemplified by warfarin, and direct thrombin inhibitors (DTIs), such as dabigatran, as well as factor Xa inhibitors, including rivaroxaban.
Warfarin, a prominent vitamin K antagonist family member, exerts its effect by inhibiting the enzyme VKORC1 (vitamin K epoxide reductase complex 1). By hindering this enzyme, warfarin...
2.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prognostic Value of C-Reactive Protein-Albumin-Lymphocyte (CALLY) Index for Survival in Nivolumab-Treated Metastatic Renal Cell Carcinoma.

Medicina (Kaunas, Lithuania)·2026
Same author

Early PSA Decline Predicts Survival Outcomes in Metastatic Castration-Resistant Prostate Cancer Treated with Androgen Receptor Pathway Inhibitors: A Retrospective Single-Center Study.

Medicina (Kaunas, Lithuania)·2026
Same author

Clinical and Social Determinants of Treatment Adherence in Cancer Patients: The Contributory Role of Hearing Loss.

Laryngoscope investigative otolaryngology·2026
Same author

Prognostic Role of Uric Acid-to-Albumin Ratio in Patients with Metastatic Breast Cancer Treated with CDK4/6 Inhibitors.

Journal of clinical medicine·2026
Same author

Comment on "Tolerability of immune checkpoint inhibitors for cancer treatment in frail, older patients".

Journal of geriatric oncology·2026
Same author

The role of lipid-derived indices in patients with MASLD in Turkey: a nationwide, multicenter cross-sectional study.

Scientific reports·2026

Related Experiment Video

Updated: Feb 4, 2026

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.5K

Haemogram Parameters in Vitamin D Deficiency.

Edip Erkus1, Gulali Aktas1, Burcin Meryem Atak1

  • 1Department of Internal Medicine, Abant Izzet Baysal (AIB) University Hospital, Bolu, Turkey.

Journal of the College of Physicians and Surgeons--Pakistan : JCPSP
|September 30, 2018
PubMed
Summary
This summary is machine-generated.

Elevated mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR) may indicate vitamin D deficiency. Physicians should consider vitamin D testing in patients with high MPV or NLR, particularly in areas where deficiency is common.

More Related Videos

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.8K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.4K

Related Experiment Videos

Last Updated: Feb 4, 2026

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.5K
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
12:48

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Published on: December 27, 2013

66.8K
The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury
07:27

The Murine Choline-Deficient, Ethionine-Supplemented CDE Diet Model of Chronic Liver Injury

Published on: October 21, 2017

12.4K

Area of Science:

  • Hematology
  • Endocrinology
  • Public Health

Background:

  • Vitamin D deficiency is a growing global health concern.
  • Inflammatory markers derived from routine blood tests, such as MPV and NLR, are increasingly studied for their association with various health conditions.
  • The relationship between vitamin D status and these hematological indices requires further investigation.

Purpose of the Study:

  • To investigate the association between vitamin D deficiency and specific hematological parameters, including mean platelet volume (MPV) and neutrophil-to-lymphocyte ratio (NLR).
  • To compare these inflammatory indices between individuals with and without vitamin D deficiency.

Main Methods:

  • A retrospective descriptive study was conducted using patient data from Abant Izzet Baysal University Hospital.
  • Subjects were categorized into vitamin D deficient and normal vitamin D groups based on serum vitamin D levels (threshold of 10 ng/ml for the Bolu region).
  • Demographic data, comorbidities, and laboratory results, including MPV and NLR, were collected and compared between the groups.

Main Results:

  • Vitamin D deficiency was more prevalent in individuals working indoors and those with comorbidities.
  • Significantly higher levels of Body Mass Index (BMI), MPV, and NLR were observed in the vitamin D deficient group compared to the normal vitamin D group.
  • Specific cut-off values were identified: MPV > 6.22 (89% sensitivity, 55% specificity) and NLR > 1.69 (76% sensitivity, 55% specificity) for predicting vitamin D deficiency.

Conclusions:

  • Elevated MPV and NLR can serve as potential indicators of underlying vitamin D deficiency.
  • Clinicians should consider assessing vitamin D levels in patients presenting with elevated MPV or NLR, especially in regions with a high prevalence of vitamin D deficiency.
  • These findings highlight the potential utility of routine blood test parameters in identifying individuals at risk for vitamin D deficiency.