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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Matrix-assisted laser desorption ionization (MALDI) is a powerful analytical technique used in mass spectrometry. It enables the identification and characterization of various biomolecules, including proteins, peptides, nucleic acids, and carbohydrates. MALDI is an ionization technique, widely employed in biological and medical research, as well as in fields like pharmacology and biochemistry.The analyte of interest, a biomolecule or a mixture of biomolecules, is mixed with a suitable matrix...
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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Drug Delivery: Parenteral Route01:29

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
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Drug Delivery: Miscellaneous Routes01:22

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Drug interactions occur when the pharmacological effect of one drug is altered by another substance, either enhancing or diminishing its activity. The drug whose activity is altered is known as the object drug, and the substance causing the alteration is called the agent drug or the precipitant. The net effects of these interactions are mostly undesirable, leading to decreased effectiveness or increased adverse effects. In rare cases, interactions can be beneficial, such as the enhanced...
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Laser-Assisted Drug Delivery.

A Alegre-Sánchez1, N Jiménez-Gómez1, P Boixeda1

  • 1Unidad de Láser, Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España.

Actas Dermo-Sifiliograficas
|September 30, 2018
PubMed
Summary
This summary is machine-generated.

Laser-assisted drug delivery (LADD) uses fractional lasers to create channels, enhancing topical product absorption through the skin barrier. This technique improves treatment efficacy for various skin conditions.

Keywords:
Ablative fractional laserCO(2) laserCicatrices hipertróficasHypertrophic scarsKeloid scarsLaser-assisted drug deliveryLáser CO(2)Láser fraccional ablativoQueloidesVehiculización de fármacos asistida por láser

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Area of Science:

  • Dermatology
  • Biomedical Engineering
  • Pharmacology

Background:

  • The skin's epidermis acts as a barrier, limiting topical product absorption.
  • Transdermal drug delivery aims to overcome this barrier using various physical and chemical methods.
  • Laser-assisted drug delivery (LADD) is an advanced technique utilizing lasers to enhance topical penetration.

Purpose of the Study:

  • To explore the mechanism and applications of laser-assisted drug delivery (LADD).
  • To evaluate the efficacy of LADD in enhancing the absorption of topical agents.
  • To discuss the potential of LADD in treating various dermatological conditions.

Main Methods:

  • Utilizing ablative fractional lasers, such as CO2 or erbium:YAG lasers, to create microscopic channels in the epidermis.
  • Adjusting LADD parameters based on patient-specific factors, skin condition, location, and the specific topical agent.
  • Applying various topical products, including corticosteroids, photosensitizers, and immunotherapy agents, via LADD.

Main Results:

  • LADD significantly enhances the absorption of topical molecules by creating controlled microchannels.
  • The technique has shown effectiveness in delivering agents like imiquimod and 5-fluorouracil.
  • Successful applications include treatment of scars, nonmelanoma skin cancer, and photodamage.

Conclusions:

  • Laser-assisted drug delivery is a promising method for improving transdermal drug penetration.
  • LADD offers synergistic benefits by combining laser treatment with topical therapy.
  • Customizable parameters make LADD adaptable for diverse dermatological applications.