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Updated: Feb 4, 2026
06:17
Expression and Purification of Virus-like Particles for Vaccination
Published on: June 2, 2016
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[From vaccine manufacturing to its availability in pharmacy]
113, rue d'Algérie, 69001 Lyon, France.
Revue Des Maladies Respiratoires
|September 30, 2018
Summary
Manufacturing vaccines presents unique challenges due to biological production complexities. Adapting vaccine supply to meet global demand remains difficult despite ongoing advancements in the vaccine industry.
Area of Science:
- Biotechnology
- Pharmaceutical Manufacturing
- Vaccinology
Background:
- Overview of the global vaccine industry.
- Regulatory requirements for biological product manufacturing.
- Introduction to vaccine production processes.
Purpose of the Study:
- To present the biological and pharmaceutical manufacturing of vaccines.
- To discuss specific challenges and characteristics of vaccine production.
- To analyze the difficulties in adapting vaccine supply to demand.
Main Methods:
- Review of vaccine industry standards.
- Analysis of biological manufacturing processes.
- Discussion of regulatory frameworks for biologics.
Main Results:
- Vaccine production is characterized by tight flow and structural delicacy.
- Controlling biological hazards is a critical aspect of vaccine manufacturing.
- Vaccine production systems exhibit weak reactivity to demand fluctuations.
Conclusions:
- Adapting vaccine supply to meet demand "at any time and in any place" remains a significant challenge.
- Inherent complexities in biological production limit supply chain flexibility.
- Continuous efforts are needed to improve vaccine manufacturing and supply chain responsiveness.
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