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Morin decreases galectin-3 expression and sensitizes ovarian cancer cells to cisplatin

Dominik Bieg1, Daniel Sypniewski2, Ewa Nowak2

  • 1Department of Biotechnology and Genetic Engineering, School of Pharmacy with the Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Katowice, Poland, Jedności Street 8, 41-200, Sosnowiec, Poland. dominik.bieg@med.sum.edu.pl.

Archives of Gynecology and Obstetrics
|September 30, 2018
PubMed
Abstract

Insights

Morin, a natural flavonoid, enhances cisplatin

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Ovarian cancer remains a significant health challenge, often developing resistance to chemotherapy.
  • Galectin-3, an anti-apoptotic protein, is implicated in cancer progression and chemoresistance.
  • Nuclear factor-kappa B (NF-κB) is a transcription factor that regulates galectin-3 expression.

Purpose of the Study:

  • To investigate if morin can sensitize ovarian cancer cells to cisplatin.
  • To determine the role of galectin-3 in morin-mediated chemosensitization.
  • To evaluate the combined effects of morin and cisplatin on ovarian cancer cell behavior.

Main Methods:

  • Assessing the effects of morin and cisplatin on ovarian cancer cell viability, proliferation, and apoptosis.
  • Analyzing galectin-3 expression at both mRNA and protein levels.
  • Utilizing cisplatin-sensitive (TOV-21G) and cisplatin-resistant (SK-OV-3) ovarian cancer cell lines.

Main Results:

  • Morin demonstrated intrinsic antitumor activity against both ovarian cancer cell lines.
  • Co-treatment with morin and cisplatin exhibited synergistic effects, sensitizing cells to cisplatin.
  • Morin significantly reduced galectin-3 expression at both mRNA and protein levels, independent of cisplatin.

Conclusions:

  • Morin effectively sensitizes ovarian cancer cells to cisplatin.
  • The chemosensitizing effect of morin is associated with the downregulation of galectin-3.
  • Morin holds potential as an adjuvant therapy to overcome cisplatin resistance in ovarian cancer.
Keywords:
CisplatinDrug resistanceGalectin-3MorinOvarian cancer

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