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Murine Surgical Model of Topical Elastase Induced Descending Thoracic Aortic Aneurysm
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Epigenetic influences on genetically triggered thoracic aortic aneurysm.
Stefanie S Portelli1, Elizabeth N Robertson2,3, Cassandra Malecki2
1Discipline of Pathology and Bosch Institute, The University of Sydney, Sydney, NSW, 2006, Australia. stefanie.portelli@sydney.edu.au.
Biophysical Reviews
|September 30, 2018
Summary
Epigenetic factors like DNA methylation influence genetically triggered thoracic aortic aneurysms (TAAs). Understanding these modulators may offer new therapeutic strategies for TAAs, improving patient outcomes.
Area of Science:
- Genetics and Epigenetics
- Cardiovascular Disease Research
Background:
- Genetically triggered thoracic aortic aneurysms (TAAs) represent a significant portion of all TAAs, leading to severe health consequences.
- Epigenetic factors are increasingly recognized for their role in modifying disease phenotypes, presenting potential therapeutic targets.
Purpose of the Study:
- To review epigenetic modulators associated with genetically triggered TAAs.
- To explore the clinical translation potential of these epigenetic factors in managing TAAs.
Main Methods:
- Literature review focusing on epigenetic mechanisms.
- Analysis of studies linking epigenetic modulators to genetically triggered TAAs.
Main Results:
- Identified key epigenetic modulators including DNA methylation, histone modification, and non-coding RNA.
- Highlighted associations between these modulators and the development or progression of genetically triggered TAAs.
Conclusions:
- Epigenetic modifications play a crucial role in genetically triggered TAAs.
- Targeting epigenetic pathways offers promising avenues for future clinical interventions in TAA management.
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