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Matrix metalloproteinase-10 deficiency delays atherosclerosis progression and plaque calcification

Ana Purroy1, Carmen Roncal2, Josune Orbe2

  • 1Laboratory of Atherothrombosis, Program of Cardiovascular Diseases, CIMA, University of Navarra, Pamplona, Spain; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.

Atherosclerosis
|September 30, 2018
PubMed
Abstract

Insights

Matrix metalloproteinase-10 (MMP10) promotes atherosclerosis and vascular calcification by increasing inflammation and plaque complications. Its absence significantly reduces lesion size and calcification in mice.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Vascular Biology

Background:

  • Matrix metalloproteinases (MMPs) are implicated in atherosclerosis and vascular calcification.
  • MMP10 is present in human atheroma but its role in atherogenesis is unclear.

Purpose of the Study:

  • To investigate the role of MMP10 in atherosclerosis and vascular calcification.
  • To analyze MMP10's association with subclinical atherosclerosis and plaque complications.

Main Methods:

  • Measured serum MMP10 levels in patients with subclinical atherosclerosis.
  • Utilized ApoE-deficient mice crossed with MMP10-deficient mice to study atherosclerosis progression.
  • Assessed plaque characteristics, inflammation, and in vitro vascular smooth muscle cell calcification.

Main Results:

  • MMP10 serum levels correlated with coronary calcification.
  • MMP10 expression was localized to atherosclerotic lesions and complicated plaques.
  • Mice lacking MMP10 exhibited reduced lesion size, macrophage content, and plaque calcification.

Conclusions:

  • MMP10 promotes atherosclerosis by driving inflammation and plaque development.
  • Absence of MMP10 delays plaque progression and alters cellular composition.
  • MMP10 is a potential therapeutic target for atherosclerosis and vascular calcification.
Keywords:
AtherosclerosisCalcificationInflammationMacrophageMetalloproteinases

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