Related Experiment Video
Updated: Feb 4, 2026
14:26
Genome-wide Purification of Extrachromosomal Circular DNA from Eukaryotic Cells
Published on: April 4, 2016
25.9K
Genome-wide identification of enhancer elements in the placenta
Majd Abdulghani1, Ashish Jain2, Geetu Tuteja3
1Department of Genetics, Development and Cell Biology, Iowa State University, Ames, IA, 50011-1079, USA; Interdepartmental Genetics and Genomics, Iowa State University, Ames, IA, 50011-1079, USA.
Placenta
|October 1, 2018
Summary
Identifying all placental enhancers is crucial for understanding gene regulation during pregnancy. This review covers methods for genome-wide enhancer discovery to advance placental research.
Area of Science:
- Genomics
- Developmental Biology
- Reproductive Medicine
Background:
- Normal placental development requires precise gene expression control.
- Enhancers are key regulatory elements influencing gene expression.
- Previous placental enhancer studies were limited in scope.
Purpose of the Study:
- To review genome-scale enhancer identification methods.
- To summarize existing placental enhancer studies.
- To guide future research in placental gene regulation.
Main Methods:
- Review of current techniques for genome-wide enhancer identification.
- Analysis of studies applying these techniques to placental research.
Main Results:
- Current methods allow for genome-scale enhancer identification.
- Holistic approaches are necessary for systems-level understanding.
- Limited studies have applied these methods comprehensively to the placenta.
Conclusions:
- Genome-wide enhancer identification is advancing.
- Further application in placental research is needed for a comprehensive understanding.
- This review provides a framework for future placental enhancer studies.
Related Concept Videos
01:11Genome-wide Association Studies-GWAS
15.7K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
15.7K
01:27Elements and Compounds
105.0K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond.
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
Elements
Elements are classified as atomic or molecular based on the nature of their basic units. They are unique forms of matter with specific chemical and physical properties that cannot break down into smaller substances by ordinary chemical reactions. There...
105.0K
04:00Periodic Classification of the Elements
59.2K
The periodic table arranges atoms based on increasing atomic number so that elements with the same chemical properties recur periodically. When their electron configurations are added to the table, a periodic recurrence of similar electron configurations in the outer shells of these elements is observed. Because they are in the outer shells of an atom, valence electrons play the most important role in chemical reactions. The outer electrons have the highest energy of the electrons in an atom...
59.2K
02:02Genomics
40.7K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
40.7K
02:54Classification of Elements and Compounds
73.2K
Pure substances consist of only one type of matter. A pure substance can be an element or a compound. An element consists of only one type of atom, while a compound consists of two or more types of atoms held together by a chemical bond. Elements are classified as atomic or molecular based on the nature of their basic units.
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
Compounds are pure substances composed of two or more elements in fixed, definite proportions. Compounds are classified as ionic or molecular (covalent) based on the bonds...
73.2K
02:35Key Elements for Plant Nutrition
24.3K
Like all living organisms, plants require organic and inorganic nutrients to survive, reproduce, grow and maintain homeostasis. To identify nutrients that are essential for plant functioning, researchers have leveraged a technique called hydroponics. In hydroponic culture systems, plants are grown—without soil—in water-based solutions containing nutrients. At least 17 nutrients have been identified as essential elements required by plants. Plants acquire these elements from the...
24.3K