Related Experiment Video

Updated: Feb 4, 2026

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants
07:26

Isolation and Characterization of Human Umbilical Cord-derived Mesenchymal Stem Cells from Preterm and Term Infants

Published on: January 26, 2019

15.1K

Long-Term Neurodevelopment of Low-Birthweight, Preterm Infants with Patent Ductus Arteriosus

R Thomas Collins1, Robert E Lyle2, Mallikarjuna Rettiganti3

  • 1Department of Pediatrics, Division of Pediatric Cardiology, Stanford University School of Medicine, Stanford, CA; Lucile Packard Children's Hospital Stanford, Palo Alto, CA.

The Journal of Pediatrics
|October 1, 2018
PubMed

Insights

The presence of a patent ductus arteriosus (PDA) in preterm infants does not affect long-term neurodevelopmental outcomes. This study analyzed data from the Infant Health and Development Program, finding no significant differences in cognitive or behavioral development.

Area of Science:

  • Neonatal Medicine
  • Developmental Pediatrics
  • Pediatric Cardiology

Background:

  • Patent ductus arteriosus (PDA) is a common condition in preterm infants.
  • The long-term neurodevelopmental impact of PDA in this population remains a concern.
  • Early identification and management strategies for PDA are crucial.

Purpose of the Study:

  • To investigate the association between PDA in preterm infants and long-term neurodevelopmental outcomes.
  • To determine if PDA presence influences cognitive development and behavioral competence.
  • To provide evidence for clinical decision-making regarding PDA management.

Main Methods:

  • Secondary observational analysis of 1090 preterm, low-birthweight infants from the Infant Health and Development Program (IHDP).
  • Longitudinal assessment of neurodevelopmental outcomes from 3 to 18 years of age.
  • Multivariable analysis adjusted for key confounding factors including birth weight, gestational age, and socioeconomic variables.

Main Results:

  • Infants with PDA had significantly lower birth weight and gestational age, and higher rates of ventilator days, vasopressor use, and congestive heart failure.
  • No significant differences were observed in maternal education or Home Observation Measurement of the Environment (HOME) scores between groups.
  • Multivariable analyses revealed no between-group differences in cognitive development or behavioral competence at ages 3, 8, and 18 years.

Conclusions:

  • The presence of a PDA in moderately preterm, low-birthweight infants does not appear to negatively impact long-term neurodevelopmental outcomes.
  • These findings suggest that PDA may not be a significant independent predictor of neurodevelopmental deficits in this cohort.
  • Further research may explore specific subgroups or alternative outcome measures.
Abstract

Keywords:
low birth weightneurodevelopmental outcomepatent ductus arteriosuspreterm

More Related Videos

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs08:58

Development of a Neonatal Piglet Acute Lung Injury Model Recreating the Early Environment of Preterm Infant Lungs

Published on: October 31, 2025

647
A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

Published on: January 12, 2018

13.5K

Related Concept Videos

Long-term Depression01:05

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.3K
Long-term Depression01:03

Long-term Depression

Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
3.4K
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
302
Long-term Potentiation01:35

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.7K
Long-term Potentiation01:25

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
3.6K
Directional Terms01:14

Directional Terms

Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
16.5K